So last week I was having the worst fatigue so far apart from when I had pneumonia. I’ve taken antibiotics for a few days now and the infection is clearing. I’m also less fatigued and more able to walk. Almost back to my new normal.
This dramatic fatigue with a relatively minor infection (I also got a fair bit of fast heart rate) makes me wonder: how much of fatigue in CLL is caused by untreated, unrecognized, small pockets of bacterial infection that we don’t get many symptoms for precisely because one immune systems are so sluggish. So a temperature, pus, inflammation and hence pain, redness, warmness around a wound, fluid released into lung tissue giving rise to the symptoms of pneumonia, and even excess sputum and mucus are ALL caused by the immune reaction to an infection not the bacteria itself.
This leads me to another question. For people who’s immunoglobulin is low and they suffer from repeated infection, the idea of IVIG is simply to replace antibodies that are lacking and so make the immune system work better. So, of course if you are given IVIg you should get less infections and your body should clear them faster.
Does that result in a reduction of people’s fatigue?
I’ve not spoken to anyone who’s had IVIG apart from one person who’s on it just now. What’s the lived experience in this group and does anyone have links to any clinical papers on this?
Also is there clear agreed international criteria for starting it anyone is aware of? Certainly the UK/EU license is very vague about how to decide when it’s time to start.
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