Very high neutrophils

[Poohey]

Hi

My husband has been prescribed injections twice weekly to boost his neutrophils which had gone as low as 0.6. He had a blood test yesterday which showed they have increased greatly to about 37.0 over a period of only three weeks. This level seems extremely high, what does this mean and is it a worry? Obviously he's been told to stop the injections and he's due to have another blood test in six days time.

He's on the Flair trial.

Any information or advice please.

[lankisterguy Volunteer]

Hi Poohey,

When I got a single injection of Neulasta in the past, my Neuts zoomed from 1.0 to 8.7 in one day. At my next clinic visit, 2 weeks later I was back to normal ANC.

This Wikipedia link has lots of information: en.wikipedia.org/wiki/Neutr...

including this snip:

"The average lifespan of inactivated human neutrophils in the circulation has been reported by different approaches to be between 5 and 90 hours.[17] Upon activation, they marginate (position themselves adjacent to the blood vessel endothelium) and undergo selectin-dependent capture followed by integrin-dependent adhesion in most cases, after which they migrate into tissues, where they survive for 1–2 days.[18]"

Len