My dad who is a 56 yrs old had suffered from ibrutinib pain. It was mainly in knee and legs. As we know normal analgesics such as acetaminophen or gabapentin have interaction with imbruvica. We started using morphin each 4h. The pain strength was reduced but a dull pain was remained.
We added nortriotyline pill 3times a day.
No pain is there now after a week!
The only problem is his muscle force r reduced. He has tremore too. However i think in comparison with that severe pain this symptom is nothing.
A comment for drs: I have monitored his BP and it is normal. Although it is will cause adduction but who cares! Its better than stopping the medicine because of pain!