Hi,
One of the most urgent unmet needs in CLL is Richter's Transformation when CLL turns bad and transforms into usually an aggressive diffuse B cell lymphoma. At the iwCLL meeting in Manhattan last May, I had the chance to talk to Dr. John Pagel about the research being done with PD-1 inhibitors for Richter's. You can listen to our conversation or read the transcript here: cllsociety.org/2017/08/iwcl...
If you didn't have a chance to read Adrian Wiestner's article on Richter's Transformation in The CLL Tribune, you can read his very comprehensive article background here: cllsociety.org/2017/04/rich...
Best
Brian