Zydelig (idelalisib) first line... NO!

[Cllcanada]

I have had a few emails and PMs asking about the use of Zydelig (idelalisib) for first line, since patients know I'm on this combined with rituxan.

I direct you to the newly revised drug label, which states...

1 INDICATIONS AND USAGE

1.1 Relapsed Chronic Lymphocytic Leukemia

Zydelig is indicated, in combination with rituximab, for the treatment of patients with relapsed chronic lymphocytic leukemia (CLL) for whom rituximab alone would be considered appropriate therapy due to other co-morbidities.

Limitation of Use

Zydelig is not indicated and is not recommended for first line treatment of patients with CLL.

Also note, that the black box warning have been just updated to include Fatal and serious infections...

gilead.com/~/media/Files/pd...

I hope this answers some questions...

~chris

[Name-1]

How are You with R+I ,Chris?Any reactions? Laboratory (ALT,ALS etc)?

Olga

[Cllcanada Top Poster CURE Hero in reply to Name-1]

All good... absolute lymphocyte count [ALC] is down to 128K from 360K... platelets and hemoglobin are up...

Some bruising, but very minor... 😀

~chris

[Name-1 in reply to Cllcanada]

I'am glad You feel good and that treatment is going in the right direction.

Thanks for Your response

Olga

[stewie]

That's great news Chris...fingers crossed that it's going well and continues....Stewie...

X

[chemosuxs]

im on the same rituxin every 2 weeks (3 so far) and zyledig 150 tabs twice a day...how long have you been on it

[Cllcanada Top Poster CURE Hero in reply to chemosuxs]

I was on it for 14 months.. it got all my numbers into range... it was great, no side effects, a few months of diarreha .. but that for me was the rituxan.... Unfortunately a treatment for secondary cancer has put everything on hold...

~chris