Zydelig (idelalisib) first line... NO!

Zydelig (idelalisib) first line...  NO!

I have had a few emails and PMs asking about the use of Zydelig (idelalisib) for first line, since patients know I'm on this combined with rituxan.

I direct you to the newly revised drug label, which states...


1.1 Relapsed Chronic Lymphocytic Leukemia

Zydelig is indicated, in combination with rituximab, for the treatment of patients with relapsed chronic lymphocytic leukemia (CLL) for whom rituximab alone would be considered appropriate therapy due to other co-morbidities.

Limitation of Use

Zydelig is not indicated and is not recommended for first line treatment of patients with CLL.

Also note, that the black box warning have been just updated to include Fatal and serious infections...


I hope this answers some questions...


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4 Replies

  • How are You with R+I ,Chris?Any reactions? Laboratory (ALT,ALS etc)?


  • All good... absolute lymphocyte count [ALC] is down to 128K from 360K... platelets and hemoglobin are up...

    Some bruising, but very minor... 😀


  • I'am glad You feel good and that treatment is going in the right direction.

    Thanks for Your response


  • That's great news Chris...fingers crossed that it's going well and continues....Stewie...


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