My mother is about to start treatment with Ibrutinib, I couldn´t convince the hematologist to start directly with Acalmbrutinib because is not aprove by the FDA in frontline. Today we have a new study and find out that she has 17p deletion/p53 positive. I know there are some other things you can do to avoid nausea, diarrea, bleedings, muscular pain, and low platelet counts, like lower the dosis to 140mg per day, grapefruit juice and Cannabis Oil. Also Celebrex. Do you know what to do?