One thing I've learned recently from references provided by Cllcanada and SeymourB is that our immune protection in our skin is quite different from that in our blood, though signals resulting from say a cut, do trigger the arrival of the first defenders from our blood stream, our neutrophils. Seems that there is a lot still to learn about how our largest organ - our skin, protects us from outside infection:
gizmag.com/skin-immune-syst...
Issues with skin irritations get a regular regular airing on CLL forums, so it is encouraging to know that we are gradually learning more about what keeps us protected from what's not us .
Neil