Non-Germinal Center B-cell Diffuse Large B-cell Lymphoma (DLBCL) may benefit most from Immunochemotherapy.

[AussieNeil]

"Progression-free and overall survival were significantly longer in patients with non-GCB DLBCL who were treated with R-ACVBP compared with R-CHOP. No differences in survival between regimens were found for patients with GCB DLBCL."

More from the Cancer Network:

cancernetwork.com/news/non-...

Good to see there is work going on in (from Paris, France in this case) into what works best for the different types of DLBCL

Neil

Photo: Flowering sundew

[Cllcanada Top Poster CURE Hero]

Actually, Non-Germinal Center B -Cell like DLBCL is not a Richter's transformation, per say, it is Activated B-cell like ABC-DLBCL or perhaps not otherwise specified or NOS-DLBCL, subtype.

RT-DLBCL is different genetically... and has two further subtypes... CLL clonal related and denovo.

en.m.wikipedia.org/wiki/Ger...

Anyway... ABC type is the hardest to treat, so this cocktail is good news... Also Imbruvica (ibrutinib) has shown to be active in this type.

A Phase II study in DLBCL found a clinically meaningful response to ibrutinib monotherapy (overall response rate [ORR] 40%, CR 8%) in the activated B-cell-like (ABC) molecular subtype, but not in the germinal B-cell-like (GBC) subtype (ORR 5%, CR 0%). Median PFS in the ABC responders was 5.5 months.

lymphomahub.com/agents/agen...

Here is the full paper

jco.ascopubs.org/content/ea...

~chris

[AussieNeil Partner Administrator in reply to Cllcanada]

Thanks for the correction Chris. Are you able to reassure our community that there's virtually no risk of developing Non-Germinal Center B -Cell like DLBCL if you have CLL?

I've changed the title.

Neil

[Cllcanada Top Poster CURE Hero in reply to AussieNeil]

DLBCL is highly aggressive... any type... I know...

De novo could be any subtype of DLBCL ...it is MUCH more secondary cancer than a true Richter's... which is clearly CLL clone related in 80% of cases... but it might be related to the brake failure on the CLL immune system car post treatment...

This will be likely reclassified based on new genetic data... CLL and NOS

perhaps?

It is just how fine you want to slice the salami

Richter's is VERY POORLY understood.. no reassurances... but RCHOP can and has been curative...

My prognosis... 6 months to a year... now I'm 24 months...

Don't believe the numbers, believe in yourselves... every day is a gift

[Psmithuk in reply to Cllcanada]

keep going - five years next! All the best

Chris(UK)