I have been on Imbruvica for two weeks and really not feeling much better. My spleen is so enlarged that I look 6-7 months pregnant, at 68! My last week labs had my WBC at 204.6 with lymphs at 194.5. Do not have many large lymphs only spleen. Anyone else on Imbruvica with similar systems, if so how long before things started getting better. I am so tired of not feeling well!