Are the chromosomal abnormalities used for prognostic indications mutations that the SLL/CLL has caused or did we have them from birth?

For instance, is 17p deletion or IVGH mutation a feature of the SLL/CLL, or a feature of our chromosomes from birth?

[Cllcanada Top Poster CURE Hero]

17p deletion is usually a missing part of the short arm of half of chromosome 17, but it can be missing from both arms... double allele. When this occurs the genes located at that point are damaged, missing or mutated... in this case the gene is TP53... the tumour suppressor gene. The gene TP53, encodes an important protein p53, and lack of this protein makes the 17p deletion more aggressive CLL/SLL... much like a brake failure on your car. Hard to stop ... patients with this deletion don't respond well to some types to therapy, however they so well on small molecules like Imbruvica (ibrutinib).

There are genetic defects in CLL passed down in families, but they have not be identified as yet... there are a number of candidates...

Here is a good article on IGHV@ gene and B cell receptors

medscape.com/viewarticle/71...

You must be a Medscape member to read, but it is free to join, well worth the time and effort to do so....

[Hidden in reply to Cllcanada]

Thanks for this.

[zevkalman in reply to Cllcanada]

This is a very interesting paper. It explains a lot of things I've been wondering about. Thanks.