New international study in Blood Journal ... has found that ...
Richter's occurs in up to 15% of CLL
Two main genetic pathways lead to the transformation
Two groups are involved
Trisomy 12 is involved in 1/3 of cases
Cell cycle inactivation of TP53 and of CDKN2A was found in 50% of cases
Richter syndrome has genomic complexity intermediate between chronic lymphocytic leukemia and diffuse large B-cell lymphoma.
RS shared some of the lesions seen in de novo DLBCL, but its genomic profile was clearly separate.
The CLL-phase preceding RS had not a generalized increase in genomic complexity when compared with untransformed CLL, but it presented clear differences in the frequency of specific genetic lesions.
Abstract:
bloodjournal.hematologylibr...
Generic breakdown supplement:
Questions for consultant?
Ibrutinib and A1c drop
Interesting recently published overview of Chronic Lymphocytic Leukaemia and Hairy-Cell Leukaemia
Bands cell count has been added to my CBC blood tests - Why?
