I am a man of 63 and after resisting taking a Statin that my DR kept advising me to take, because of a heightened risk of heart attack because of my high BP. I succumbed. It took my Cholesterol ratio from 5.9 to 3.6 happy yes.... The problem I have always exercised aerobic on the treadmill 5+km 4 days 43mins at 7kmh and 2min HIT at 9km also 4 days moderate loose weights upper body workout . These exercise's up until now kept my midriff reasonably trim, but recently on the statin there has been a gradual thickening of the waist nothing drastic, but it worries me if I cut back any, what would happen. I then read this report
researchers from the University of Missouri and other institutions gathered a group of overweight, sedentary men and women, all of whom had multiple symptoms of metabolic problems, including wide waistlines, high blood pressure or excess abdominal fat.
Most had slightly but not dangerously elevated cholesterol levels.
None had exercised regularly in the past year.
All underwent muscle biopsies and treadmill testing to determine their aerobic fitness — which was generally quite low — and agreed to continue with their normal diet.
Then they all began a supervised 12-week exercise program, during which they visited the university lab five times a week and walked or jogged on a treadmill for 45 minutes at a moderately vigorous pace (about 65 to 70 percent of their individual aerobic maximum).
Half of the group also began taking a daily 40-milligram dose of simvastatin, a particular type of statin sold under the brand name Zocor.
At the end of 12 weeks, the participants fitness and muscles were retested.
Statins, as most of us know, are medications designed to reduce the body’s cholesterol levels, particularly levels of low-density lipoprotein, or “bad” cholesterol. The drugs routinely are prescribed for those with high cholesterol and other risk factors for heart disease, and some physicians believe that they should be used prophylactically by virtually everyone over 50.
Exercise also typically is recommended as a means of fighting heart disease and prolonging life span.
And both statins and sweating indisputably are effective. In past studies, researchers have shown that statins reduce the risk of a heart attack in people at high risk by 10 to 20 percent for every 1-millimole-per-liter reduction in blood cholesterol levels (millimoles measure the actual number of cholesterol molecules in the bloodstream), equivalent to about a 40-point drop in LDL levels. Meanwhile, improving aerobic fitness by even a small percentage through exercise likewise has been found to lessen someone’s likelihood of dying prematurely by as much as 50 percent.
So, theoretically, it would seem that combining statins and exercise should provide the greatest possible health benefit.
But until the current study, no experiment scrupulously had explored the interactions of statin drugs and workouts in people. And the results, as it turns out, are worrisome.
The current study, no experiment scrupulouslyhad explored the interactions of statin drugs and workouts in people. And the results, as it turns out, are worrisome.
The unmedicated volunteers improved their aerobic fitness significantly after three months of exercise, by more than 10 percent on average. But the volunteers taking the statins gained barely 1 percent on average in their fitness, and some possessed less aerobic capacity at the end of the study than at its start.
Why there should be such a discrepancy between the two groups’ fitness levels wasn’t clear on the surface. But when the researchers looked microscopically at biopsied muscle tissue, they found notable differences in the levels of an enzyme related to the health of mitochondria, the tiny energy-producing parts of a cell. Mitochondria generally increase in number and potency when someone exercises.
But in the volunteers taking statins, enzyme levels related to mitochondrial health fell by about 4.5 percent over the course of the experiment. The same levels increased by 13 percent in the group not taking the drug.
In effect, the volunteers taking statins “were not getting the same bang from their exercise buck” as the other exercisers, says John P. Thyfault, a professor of nutrition and exercise physiology.
This must be bad news for overweight people on statins that their exercising is negated by the statin keeping them overweight .... the thought is exercise to get the weight down before starting on statins ...
but for people like me I have a problem, as I don't want to discontinue the statin and waste the benefit of the 3.6 but also don't want an increase in waistline... So since this report is there a way round it or do athlete trainers , nutritionists know what I can do exercise wise to negate the statin effect ?