I have just bought some ubiqinol to try to counteract the effects of two yrs on 80mg of avorstatin a day.
They are 100mg softgels and the dose is one tab three times a day. Do I really need to take 300mg a day? From what I've read a 100mg/day is adequate...Obviously at that price the manufacturer says I do but I wonder??
Scrumpyjax are you still taking avorstatin? If yes then you'll need the high dose of Ubiquinol 300mg a day is average for anyone on statins.
If you've just stopped taking statins and are trying to heal any side effects then start with 200 to 300mg a day and gradually reduce to 100mg a day after a few weeks.
Hope that helps
What is this dosing recommendation based on?
I had angioplasty in 2012 and one stent. The medication when I left the cardiac dept was Clopidogrel for a year. 80mg Avorstatin and 75mg soluble aspirin plus my usual BP medicine-Amlodipine 10mg and Ramipril 10mg. My chlorestrol was 2.9 in Jan 2014 and my BP average was good. My GP says I will always have to take the statins to keep my chlorestrol down?
Since I have stopped taking them I feel better,sleep better,ache less,have more energy. I am taking 300 mg Ubiquinol daily and eating sensibly.
Hi AMP
My recommendations are based on reading studies, personnel experience and most importantly others experiences.
Happy to see Daveshome's post as that's a another piece of literature I've read
Hi Prof Peter Langsjoen has a brilliant article about STATINS & Q10. He recommends 100mg 3x a day to start with
Hope that helps AMP
Do you trust this Langsjoen? He will sell you a “life extending pill” if he can. He is under no obligation to prove what he is saying and does’t far as i can see.
If you have a link to the studies it would be good to read them.
Hi AMP
There are so many studies on the benefit of Ubiquinol to many to post links here, if you google Ubiquinol clinical studies you'll find plenty to read.
In Canada they only prescribe statins on the condition that patients are offered Ubiquinol.
If you have trouble finding any studies, I'll be happy to add a couple of links
Humm i’m difficult to convince i looked through google scalar and pulled the quality peer reviewed analysis. On this basis at least the meta studies suggested that there is either contradictory evidence or no evidence that this co enzyme affects muscle myopathy.
It’s interesting that you say it’s recommended in Canada. Canada is not like the UK there in’t a national recommendation , it goes state by sate - do you know which state it was? Would be good to look it up. I looked at the German and French guidance they, along with the UK don’t recommend it.
I wish there was better information. If it really is a help great, if not who knows what complications are added by taking it.
Ubiquinol is the reduced form of Co Q10 which is an essential nutrient.
Statins inhibits the bodies production of Co Q10
So if you are on a statin drug, you can now understand why your doctor may have suggested that you take coenzyme Q10 or Ubiquinol alongside it.
In Canada, statin drug packages include a black box warning recommending that they be taken in conjunction with coenzyme Q10.
Below are a list of studies
Passi S, Stancato A, Aleo E, Dmitrieva A, Littarru GP. Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA. Biofactors. 2003;18(1-4):113-24.
De Pinieux G, Chariot P, Ammi-Said M et al., Lipid-lowering drugs and mitochondrial functions: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br. J. Clin. Pharmacol. 1996;42(3):333–337.
Mortensen SA, Leth A, Agner E, Rohde M. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med Suppl 1997;18: S137–144.
Watts GF, Castellucci C, Rice-Evans C et al., Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. J. Clin Pathol. 1993;46(11):1055–1057.
Hargreaves IP, Duncan AJ, Heales SJ, Land JM. The effect of HMG-CoA reductase inhibitors on coenzyme Q10: possible biochemical/clinical implications. Drug Saf. 2005;28(8):659-76.
Thank you. I appreciate you posing these i will read them. I’m not sure they are specifically what i’m looking for. The titles suggest non of these studies are specifically testing if taking supplementation changes q10 levels or if the reduction in q10 caused by statins is in fact a problem. I think there is a hole here, hence why q10 is not recommended in most countries - there is no clinical evidence for it. The metabolic pathways involving this particular co-enzyme and potential for statins to interact are well understood, and there is looks like these articles discuss that, it isn’t the same thing as understanding the clinical relevance. i would love to have some positive clinical evidence and there isn’t any long term study on the effect positive and negative. Without it who know what i’m taking.
Thank heavens someone who has sense to state that no peer review has taken place,therefore no proof of the efficacy of Q10 or ubiqanol
Thanks Sonyajba.
I stopped the statins a couple of weeks ago and already feel a lot better in myself. There is no doubt in my mind that the statins have caused my problems.
I will start on 300mg for a while then bring it down. My diet is good anyway but I will try and fine tune it. My cholesterol was 2.9 in January!!....When I am happy with my health I will be back to my GP for another chol test and some hard talking....I was diagnosed with angina and had an angioplasty in Feb 2012 so I might be in the at risk category.
Yeh!!! I'm working on it.
Try a low carb diet that'll keep your cholesterol in check, along with reducing sugar intake that also means low fat products as they're full of sugar. Avoid tran fats and veg oil, use animal fat for cooking like goose or duck fat. Best and healthiest cooking oil is coconut oil but it's an acquired taste.
Follow these simple rules and you should find your cholesterol stays lower than pre statins that way no medication needed.
Good luck
I Like this bit.."Follow these simple rules and you should find your cholesterol stays lower than pre statins that way no medication needed."
Hi Prof Peter Langsjoen has a brilliant article about STATINS & Q10. He recommends 100mg 3x a day to start with. Perhaps use natural cholesterol lowering supplements & diet & lower your statins & q10 if this works. Best wishes Dave
Have been taking 120mg of CQ10 for 5 years and it is the best thing I have done,on20mg of Atorvastatin now after being on 10mg of Rosuvastat for since 2006. The main concern with me is the price of ubiquinol, how much.
would you pay for 300mg of Ubiqinol per day, I know your health is priceless , but it would be very expensive in the UK.?
I got mine on Ebay and paid £18.33 for Ubiquinol 100mg x 60 Softgels- Kaneka QH.
Scrumpjax, thanks, will check it out.
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