I was told by my doctor to take it twice a day [I think she said random times, not sure on that] and take it twice/three times with a minute or two in between. Then choose the lowest number and to do this for a week, working out an average reading. NOW she says goalposts have changed and to take 2 readings a day for a week, using all numbers to work out an average. BUT every time I take a reading the first one is always about 20 points higher than the second or third. Why is this and should I be using what I consider is an artificially high number? I am on 50 mg Losartan btw. When I have it taken in the surgery it goes quite off the page [200/100 the last time] so it's a good job I have the home monitor or I I would be over medicated - that's my feeling anyway.