Hello I'm asking for help, we are losing hope. My sister, who is 54 years old since november 2017 has broken 11 vertebrae it was not caused by fall or some injury. To this day, doctors do not now how to diagnose the illness or find the cause. The calcium is losing and is not saving to the bones. The bone marrow, onkomarkers, histology are negative. She has highly positive ANA, osteoporosis and not defined focus of femur bone. She has positive scleroderma and systemic sclerosis. She is suffering from terrible pains and she is using only vitamin D- calcium and analgetics. I hope someone will help. Thank you.