I am a new member, 82, male, and suffer with C.O.P.D. My Seretide inhaler, which was very beneficial, was recently changed to Sirdupla. The side effects of Sirdupla, over the five weeks I took it, were horrific - bronchitis, thrush in the mouth, swollen throat, leg cramps, violent aggressive nightmares, etc. I am now back on Seretide, and recovering slowly. I am concerned that some lasting damage may have been caused by the Sirdupla.