There is some interesting research here that suggests mitochondria rather than glucose or insulin levels may drive inflammation particularly in Type II Diabetes:
It Might be Mitochondria: There is some... - British Heart Fou...
It Might be Mitochondria
MichaelJHHeart Star
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MichaelJH
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How extraordinary. This finding may lead to profound changes in disease management and raises in my mind the question of whether such changes might be driving inflammation in many of us CVD patients. Early days!
Thank you for the interesting information.
in reply to JonathanH
Maybe, in 20 years time.
In fact, this concept is nothing new as far as I am aware.
Mito is implicated in several other major diseases.
But they will refuse to believe the study results anyway.
They cannot suddenly change the way they work.
You go to hospitals and go to your "department" for your particular
disease.
They wouldn't suddenly be demolishing these departments.
"let's look at your Mito". There is no cure for Mito damage.
It's a bit like trying to fix damaged DNA.
in reply to
By DNA editing?
Wow so scientists were wrong about saturated fat, probably wrong about cholesterol being the main cause of heart disease and now wrong about glucose and diabetes.
It's no wonder that people loose faith in the medical community regarding health advice as it seems that they are wrong so often and for over 50 years now regarding heart disease.
They are wrong about cholesterol, lots of new studies now to back that up.
in reply to fergusthegreat
It says: "The team was surprised to find that glycolysis wasn't driving chronic inflammation. Instead, a combination of defects in mitochondria and elevated fat derivatives were responsible."
Elevated fat derivatives!
Where did these come from??
What are they?
It has also been known for a long time that Lp(a) is a strong indicator of heart disease risk, yet try and find a GP willing to do the blood test. sciencedirect.com/science/a...
I asked because my father, his brother and their father all dropped dead prematurely but was refused as it was "researcher"! Subsequently angina and then quadruple bypass!
in reply to MichaelJH
Doctors generally don't know enough about autoimmune disease. . .
in reply to Adaboo
Mine is likely "elevated".
Lab tests are useful to confirm.
But, old school medicine worked well by taking signs and symptoms
from patients.
Have you tried a private Cardio in London?
I must admit that the article is lengthy and is hard to follow. . .
Can GP understand it?
I doubt it. . . Very useful for us, patients on the other hand.
"This might also explain why some patients do not respond well to LDL-C lowering by statins, because most of their cholesterol is on Lp(a), rather than LDL particles (61), and Lp(a) can increase with statin therapy. This should be a clue to physicians that lack of response to statin therapy could be due to highly elevated Lp(a). Thus, although statin therapy results in overall benefit, it is possible that patients who have increased Lp(a) post-statin therapy do not obtain the full benefit of the statin."
Adaboo in reply to
I have had a test (privately) of course as GP wasn’t convinced. She said she would investigate more. Mine is slightly elevated which I kind of knew. They found that statins increase it which again is worrying. Some people have managed to lower their Lp(a) though, so it’s not totally impossible, just not easy. I’m trying.
If you don't mind .
What are you doing to lower your score?
I take mega dose Vit C, Vit K2 mk7 ,magnesium, coq10, aged garlic, nattokinase, Vit D, probiotics, amino acids drink and am just starting pqq. ( I have a connective tissue disorder and the pqq is for that really but I didn’t realise how much it can help mitochdria. Bonus! 🙂 I eat clean low carb ( under 100 grams a day) med healthy fat. Also intermittent fast 16 hours a day and exercise of course. Niacin is supposed to help with Lp( a) too. I’m sure people laugh at what I’m doing( I rattle 😂) but my cholesterol ratio is now optimal, triglycerides are low too with no meds! Plus all my other bloods glucose, inflammation etc all lowered too after just 3 months. I can only presume maybe my Lp(a) was maybe higher as I’ve only just had the test, so I’m hoping it may lower. I’ll test again in 3 months to check. I know of only a few people who have lowered their number naturally.
Adaboo in reply to
Interesting ncbi.nlm.nih.gov/pubmed/242...
There's another link that leads to the original paper.
The second link is the orignal paper.
MichaelJHHeart Star
In a number of my replies I have recommended 1000mg Vitamin C SR. In SR (slow release) form it is absorbed more effectively so is equivalent to 2 to 3 doses of the standard product. It also causes less acidity problems. But run it past your GP.
Always good to let your GP know what your taking I agree Michael. Mine has a little knowledge about supplements etc and is not against them but does explain she has no choice but to stick to NICE guidelines whatever her beliefs are. We don’t store Vit C so it’s mostly safe to take large amounts. Does it do any good? Who really knows 🙂 Amanda
I think the fact that it (as lime juice) prevented scurvy is a good indication in itself.
MichaelJHHeart Star
I found that quite a few think it is a slightly eccentric thing to do but both my surgeon and the admission's sister did not especially when I mentioned scurvy. The problem is that Vitamin C gets associated with colds and flu and blood vessels are rarely mentioned.
3000 iu Vit D, 150mcg VitK2, 400mg magnesium sometimes twice a day.120 mg coq10. Amino acids are in collagen peptide drink and I drink it mainly for the Lysine, proline and L arginine. Vit C varies as I take liposomal too, but I’m guessing around 6-8 grams a day. Amanda 🙂 ( my name on here makes me laugh as Ada and Boo are my dogs 😁
MichaelJHHeart Star
Extremely rare these days but it still occasionally occurs in children fed a carp diet and among alcoholics and druggies.
MichaelJHHeart Star
I remembered a news report that it was on the rise and have managed to find it:
It’s nutrizing K2 D3 and mag in one pill, but I also take more mag. The drink is mighty balance hydrolysed collagen peptides 😊
MichaelJHHeart Star
Oxford dictionary - a person of unconventional and slightly strange views or behaviour. The definition does not equate to crazy!
This might change your mind on a few things! But maybe not 😅 ncbi.nlm.nih.gov/pmc/articl...
Now if I said Vitamin C might be able to cure cancer you would definitely call me quackers 😅. Or maybe not? ncbi.nlm.nih.gov/pmc/articl... My husband has cancer but these studies prove vitamin C’s use for oxidative stress etc which affects us all !
Who me 😇😇
Ooh erase that thought from my mind 🤭Thanks for your kind wishes, he’s doing well although it’s incurable. Maybe my crazy quackery is working. 😉
That’s an amazing and heart warming story! We do low carb med fat, plus supplements of course and loads of Vit C. Hubby’s time up should of been a couple of years ago but he’s doing really well against the new odds. We need to doctor ourselves more. If he’d just done what the NHS said he wouldn’t be here and living normally now. He’s off to Iceland exploring in October, bucket list job! 🙂.
I think the cancer studies prove how much Vit C can improve oxidative stress, lipids etc which is what we are all fighting.
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