a post for someone from BHF really.

[minime01]

a post for someone from BHF really. I have been looking for more information about a new drug called Trodusquemine, which BHF trailled in Aberdeen, abdn.ac.uk/news/11280/. I cant find anything about it on the site or where they are going next?

[Nettyanne]

Hi minime just to let you know that the BHF office has only reopened today and they said there could be a delay in replying to queries while they clear the backlog.

Best wishes

[MichaelJH Heart Star]

Here's some background reading that may give you a bit more information:-

clinsci.org/content/131/20/...

However, you should note that trials on mice and other mammals do not always scale uo to humans!

[minime01 in reply to MichaelJH]

thanks for that link, I hadn't managed to find that.

[Hidden]

Hi there,

I've had a chat with our research team and at the moment there haven't been any applications to start this research into humans with coronary heart disease. It looks like there will be human trials focussing on diabetes, and if there were any positive cardiovascular outcomes then it might spur a researcher on to propose more trials.

Hope this helps,

Chris

[Maryam_BHF]

Hi minime01

Just to add to what Chris has said, I have checked with the Research Department and got a bit more detail about the study which we funded at Aberdeen University.

Trodusquemine has been previously shown to improve insulin resistance in the laboratory and we understand that the drug is currently in further early phase studies (mainly for safety) in about 20-80 patients with diabetes for this essentially different purpose.

If it is successful in those early trials for diabetes patients and is without any unwanted side effects, it will go on to be used in larger trials to see if it can reduce the incidence or consequences of diabetes in people.

That will likely take several years and a lot of funding and only then, once its safety and positive effects on diabetes are proven, will we know whether the beneficial effects on atherosclerosis are reproduced in people.

The Aberdeen group are not involved in these clinical trials – so they are not directly continuing this line of research but there is a link to their published paper here:

clinsci.org/content/early/2...

I hope this helps!

Maryam