NSAIDs Might Exacerbate or Suppress COVID-19 Depending on Timing, Mouse Study Suggests.

[2greys]

( NSAIDs = Nonsteroidal anti-inflammatory drugs, eg Aspirin, Ibuprofen, Paracetamol )

New research shows that non-steroidal anti-inflammatory drugs (NSAIDs) reduced both antibody and inflammatory responses to SARS-CoV-2 infection in mice. The study appears this week in the Journal of Virology, a publication of the American Society for Microbiology.

The research is important because “NSAIDs are arguably the most commonly used anti-inflammatory medications,” said principal investigator Craig B. Wilen, Assistant Professor of Laboratory Medicine and Immunology, Yale University School of Medicine.

In addition to taking NSAIDs for chronic conditions such as arthritis, people take them “for shorter periods of time during infections, and [during] acute inflammation as experienced with COVID-19, and for side effects from vaccination, such as soreness, fever, and malaise,” said Dr. Wilen. “Our work suggests that the NSAID meloxicam dampens the immune response to SARS-CoV-2 infection.”

asm.org/Press-Releases/2021...

Journal of Virology:

jvi.asm.org/content/early/2...

[RoadRunner44]

😄😄😄 Thanks 2greys

[Croydonia]

I know ibuprofen is anti inflammatory, but didn’t think paracetamol is classed as that?

[Annie31 in reply to Croydonia]

It isn't it's a painkiller. I found that strange myself. I can't take ibuprofen, it gives me tummy ache even when taken with food.

[2greys in reply to Annie31]

Classification as a non-steroidal antiinflammatory drug (NSAID) takes into account several peculiarities such as the ability to inhibit pain of nociceptive origin, antipyretic capacity, affinity for cyclooxygenases (COX) and among other parameters.

In the case of Paracetamol (also known as acetaminophen), it is recognized that it has an antipyretic activity (against fever) which is even its main therapeutic focus. However, it also reveals a weak anti-inflammatory activity that is often potentiated in caffeine formulations (such as Tylenol DC). Its affinity for the COX enzyme is not yet fully elucidated, as it is believed to inhibit a third isoform of this enzyme. And it is a usual drug to treat pain and fevers in pregnant and breastfeeding women, and is the first recommended for babies under 3 months of age.

Its classification as an AINES or not still generates discussions between pharmaceutical specialists and doctors. In the famous book "The Pharmacological Bases of Therapeutics (by Goodman & Gilman)" we see Paracetamol framed among NSAIDs, but in others such as "Lippincott's Modern Pharmacology (Craig & Stizel)" and "Basic and Clinical Pharmacology (Katzung), Paracetamol is set apart from NSAIDs.

NSAIDs bring together chemically heterogeneous compounds, almost always derived from acids: acetic (such as Aceclofenac), enolic (such as Meloxicam), nicotinic (such as Clonixinate), propionic (such as Ketoprofen). Not to mention pyridine derivatives (such as Phenazopyridine), pyrazole (such as Dipyrone), aniline (such as Paracetamol) and phenoxymethanesulfanilide (such as Nimesulide). Its members have varying potencies, equally varying action times, and affinity for COX isoforms oscillate among the most COX-1 inhibitors (such as Acetyl Salicylic Acid), the most COX-2 inhibitors (such as Celecoxib) and which inhibit both (such as Mephenamic Acid and Loxoprofen).

Therefore, even considering its lower anti-inflammatory capacity and recognized antipyretic action, I believe that framing Paracetamol as an NSAID (or not) is more a matter of opinion and partisanship. It is not wrong to frame it, but it is certainly not unanimous.

quora.com/Is-paracetamol-an...

Enough to to be mentioned as being one in the context of the article within the risk of Covid.

[Annie31 in reply to 2greys]

Good God! I stand corrected! The main reason I didn't think paracetamol had anti-inflammatory ingredients however weak was because my daughter with Ulcerative Colitis was always told both by Paediatric and Adult Consultant never to take Ibobrufen for the disease but to take paracetamol for pain etc and keep to the prescribed anti-inflammatory drugs for this disease. Ibuprofen can do more harm than good.

[Croydonia in reply to 2greys]

Thank you 2gs. Btw, were you in the medical profession , you are so knowledgeable!

[2greys in reply to Croydonia]

No, I was an self employed engineer and used to have my own workshop and four employees. Nothing grand just a means to earn a modest living, without having to bow down to people less qualified than myself. My father was a consultant engineer so it was natural to follow in his footsteps I suppose. I do read an awful lot and obviously my interests have shifted to medical subjects since being diagnosed. At one time I did consider studying to be a vet.

[katieoxo60 in reply to 2greys]

Thank you 2 greys interesting bit of info especially as many of us with pain take paracetamol on a daily basis.