Biological User (e.g. Omalizumab / other MAB)??

[Matman]

Would appreciate your reply to my 2 Questions below, if you’ve been using a Biological (Example Only, Omalizumab / Other) ‘for at least 3 Months’.

Leaving aside what happens during colds / infections, If you’re someone who has been using a Biological (for at least 3 months) PLUS are an Asthmatic historically prone to coughing-up Sputum / Phlegm ‘every day’:

1. Have you noticed if either the ‘volume’ or ‘frequency’ of your Phlegm / Mucus Production has changed ‘significantly’? (If so, has either the volume or frequency ‘definitely’ declined or ‘definetly’ increased?).

2. Have you noticed any definite (permanent) change in either the colour or consistency (i.e. ‘type’) of Phlegm / Mucus you produce?

Thanks in advance for any Comments / Feedback (Appreciated).

[EmmaF91 Community Ambassador]

I was on Omalizumab for 6/7 months and have been on mepolizumab for 2... I also get asthmatic bronchitis when my asthma isn’t controlled.

For me my mucus went from yellow to clear, and thinned down. And production significantly reduced (more so in mepo and I still ‘got’ asthma on xolair).

Hope that helps x

[Shellc]

That’s a really good question and one I’ve had to think about , I was on mep recently and my sputum increased , I didn’t associate it with the mep but since being off it I’m not producing any.

I didn’t know any change in consistency

[Matman in reply to Shellc]

Interesting. Thanks. I’ve been propositioned to try a Biological but have so far declined, preferring to use Pred (despite its many drawbacks). However, I’m still considering a move to a Biological. While quite active and mobile (long walks etc) I want to reduce the risk of developing Bronchietasis (which, conceivably, I’m heading for, or am already starting to suffer from). I’m aware that the primary cause of Asthma Fatalities is Mucus Blockage, hence my interest in this somewhat yucky topic.

[Shellc]

I dint think you can reduce the risk of bronchiectasis, you have either got it or you haven’t . Mine started with chest infections that lasted longer than normal , when I didn’t have infection I was very well and didn’t have any breathing problems , my bronchiectasis got worse after I had my daughter , and probably given wring advice or different from today advice , consequently got worse as years went on , the weaker my lungs git that’s when I realised I had asthma tendencies . All I can say is carry on doing your long walks , this will be helping you greatly . Keep coughing up the mucus as then infection will not take hold . Get your yourself on vitamin d high dose to help immune system

[Matman]

Cheers

[TuckBox2]

I have been on Omalizumab (4 years) & I am now on Mepolizumab (18 months), also swoped to Fostair (12 months).

I am finding the Mep a great help, I have not had any hospital admissions, I have only had 1 trip to A&E which was early on when I started on Mep. The Fostair has helped get my pf from the usual 420-480 up to 500+ 2 or 3 times a week, previously it was only once a month or so.

I have been on Carbocisteine for about 6 years to help thin out & loosen the mucus, so I can't say whether the Mep is improving this or not.

I was swoped from Omalizumab to Mepolizumab as after 2 years of being really well then I had a bout of pneumonia and things seemed to take a downturn, 6 months on daily 10mg Preds got me through one winter without any serious problems, but the 2nd year I was in hospital 3 or 4 times even while on the preds.