I had my first Methotexate injection Friday and started prednisone twice a day. I was told to take folic acid to reduce side effects but not told when to take. So I took the folic acid with the injection and prednisone. Since, I have read that I should not take folic acid the day of injection. Are there any other supplements or medications that I need to space out from the injection? Also, I have COPD and my Rheumatologist said I need to watch for a cough the first few days. I always have a cough. Has anyone had problems with side effects? I was taken off plaquenil because of glaucoma, which we hope the inflammation will reverse with this change in medication.