Interesting Article on Anticoagulants - Edoxaban - trial on low dose.

[CDreamer]

"Our study provides an important piece of the puzzle," Giugliano said. "At least now we can be informed, we can talk to our patients and say, 'I understand you didn't tolerate the standard dose…but another option is to give you a half dose of edoxaban. The good of it is your risk of bleeding is much lower; the bad side is that it doesn't protect you as well from stroke.'"

medscape.com/viewarticle/94...

[Paulbounce]

Interesting indeed CD.

It makes me think about my situation. I have been on Dabigatran for few years but decided to no longer take it. My cardio said the decision was mine. I had a chat on the phone with my GP and suggested I meet half way and have half the dose. He said no - you are either on it or off it. No middle ground. He said to carry on taking it might cause problems in later years. The cardio says to start again if I go back in to afib ready for another CV.

So at the moment I have to weigh up the risks. I don't see why there's not room to meet in the middle though.

I will certainly discuss it again with my cardio when we next chat (who knows when).

I was on 150 mg twice a day. There is a 110 mg Dabigatran which I would be happy to take once a day. Best of both worlds IMO.

I don't know what to do.

Have a great weekend.

Paul

[CDreamer in reply to Paulbounce]

I was glad to see some research on the subject and hopefully this may give your GP pause for thought.

Dabigatran didn’t suit me at all, Apixaban seems better for me but I have been wondering as I age and now I have no AF - 2 episodes in 3 years when I had infection - whether it would be an option for me but I have a Pacemaker which complicates things but I’m also on drugs which put a heavy burden on my liver and kidneys anyway. Nothing’s simple!

It’s a difficult one so I can understand your dilemma.

[Paulbounce in reply to CDreamer]

CD wrote

"Nothing’s simple!"

Yep

Paul

[KathFrances in reply to Paulbounce]

I was reluctant to take an anticoagulant as my stroke risk is low, so the cardio agreed to my taking 110mg Dabigatran twice daily instead of 150mg. I've been on it for some years with no problems.

[CDreamer]

Good analysis. Important phrase for me - High bleeding risk should not necessitate withholding anticoagulation, but should prompt careful selection of a strategy that yields the greatest benefit in proportion to risk.

[Jalia]

Ditto !

[sotolol]

I gave up with a headache.

[Dodie117]

Me too. Maybe some kind soul can paraphrase!😁

[Dodie117]

👍😂

[Dodie117]

Sorry. Just appreciating 👍 and amused 😂 by your paraphrasing

[Hidden]

Badger why delete your post, it was a useful contribution to CD’s thread. Almost all medical reports can be heavy going but that’s no reason to exclude them from the forum. Contrary to what you might think, I did pick up on the gist of what was being trialled and can certainly see the value it will bring to patients keen to reduce their risk of bleeding but maintaining a reasonable degree of protection against having a stroke. Your decision of course, but I think you should re-instate it.

[CDreamer]

No problem and FJ makes some good points in that medical reports, especially if you are not used to reading them, are heavy going.

I would be pleased to have a copy of the editorial if you could PM it to me. There was a lot of meat there and I think it is a very important subject and a perennial on this forum however I can understand that it could flummox some people when it’s not a black or white issue.

[Hidden in reply to CDreamer]

jacc.org/doi/10.1016/j.jacc...

Have found the link to the editorial which it turns out is in fact free to access