Have been on Apixaban and Bisoprolol for around 6 weeks with no particular side effects. During the day when busy, the palpitations are kept to a minimum but as soon as I get into bed they start and I find it really difficult to get to sleep. They sometimes wake me up in middle of night after which sleep is virtually impossible. Am relying on over the counter sleep aids to try and get decent night. Try deep breathing exercises with little relief. Any suggestions as feel washed out!