I was initially diagnosed with prostate cancer un 2021 and treated with 23 radiation treatments and radioactive beads.
In April of 2024 my Psa started to rise significantly and subsequent imaging showed I had stage 4 cancer that had spread to my lymph nodes. I was put on leuprolide inJune of 2024 and by December my PSA was undetectable <.02 and my testosterone was 0.
In March of 2025 my testosterone is still zero But my PSA is now .03. Should I be worried that the leuprolide is losing effect?
At MD Anderson undetectable is considered to be <0.10. You should be ok
What is causing your concern is the ultrasensitive PSA test you are taking. Switch to a traditional PSA test (lowest value 0.1 ng/ml) and you will have less anxiety.
Hear,hear.
I just can't comprehend ignoring cancer growth, nor cheering this wrongfulness.
The value of any diagnostic test (biochemical or imaging) is only based on the potential change in therapy that can be done because of it. We now have proof from 3 clinical trials that no change is warranted until PSA reaches biochemical recurrence level.
I once believed as you do, until I saw the proof with my own eyes. That's how science works -- all truths are provisional until disproven. One can either follow the science or let anxiety dictate treatment.
You can wait, as some suggest. I rely on frequent uPSA testing to establish trend, comparative imaging and liquid blood biopsy testing to not give this cancer time and obscurity.
The change you are talking about means nothing. Tests can go up and down that much. Keep positive, love life and enjoy it.
Thank you! I feel a lot better now! 👍
Your journey has been similar to mine in some ways. I was diagnosed in 2015 and it was determined that I needed to have a full Prostatectomy which I did. I was said to be cancer free for 2 years, and had zero PSA.. On the last (every 3 month) blood draw, the day I would find out if I could go on having a blood draw once a year, my PSA began to rise. They did 8 weeks of radiation to the Prostate bed which did nothing. It was then that I was stage 4. I had the one Lupron shot and it hit me so hard, but that one shot alone also kept my PSA at zero a long time. When my PSA began to rise again was when I started Orgovyx.
There are people in this forum with more clinical knowledge than me, so listen to them first, then consider me because I'm JUST SOME shmo with cancer.
First, it's scary to go from 0 to ANYTHING! I'm told the "PSA doubling rate" is what they're really watching. The gist is, if it doubles within 3 months, you LIKELY WILL need additional treatment, other than that, you're still a 'watch'. If you get into the 1.x range, I'd start beating on doors for a PSMA PET scan. The OLD line was "2.0" which my old ocno made me wait for. I'm told by my NEW onco that 2.0 is NOT the line if you've had other treatment previously. I didn't know to beat on my old onco before.
Just my limited personal experience.
Based upon today's responses, you should be able to change your UserID from Kayweiss to Kaywise....
Good Luck, Good Health and Good Humor.
j-o-h-n
And you should change yours from j-o-h-n to jitling - dork guy
Good idea...... thanks...
Good Luck, Good Health and Good Humor.
j-o-h-n
Were the lymph nodes treated with radiation when they were identified in 2024 or had they already been irradiated?
Did anyone discuss adding an ARPI like enzalutamide as per the Embark trial?
PSA Rising
Radiation not an option?
Just joined the club no one wants to be a member of in April 2023 - can Gleason 9 be cured ?
Rising PSA - 
