swelling after Pluvicto/radiation

[Oct18]

I am currently in between my fourth and fifth Pluvicto treatments. I am getting scans before the fifth to see if things are stable. After my first two treatments, my PSA was not dropping and there was a possible new spot or two on my femur. So the Dr recommended radiation to my whole right femur. Once I started the treatment with radiation, the radiologist also hit the top of my pelvic area and my SI joints as well. Then I had my third Pluvicto treatment and over the next six weeks my PSA dropped considerably from 17.65 to 5.18. While I was getting the radiation, there was some swelling through my thigh, but and I felt much better for about six weeks and the swelling did subside. Over the last couple of weeks the swelling has come back just like it did during radiation. My radiologist does not seem concerned I will discuss with my oncologist next week, but I was wondering, has anybody had an experience of swelling, not just after radiation, but having the swelling come back, possibly caused by the.Pluvicto. My PSA did go up to 6.3 a few weeks ago right about the time I started the swelling and some more soreness. Anyway, any thoughts or advice would be appreciated. Thanks to all.

[Oct18]

anyone??

[j-o-h-n]

Any swelling caused by Pluvicto / radiation?

From: Master A. and Mistress I.

ChatGPT said:

Swelling can be a potential side effect of Pluvicto (lutetium Lu 177 vipivotide tetraxetan), which is a radiopharmaceutical used in treating certain cancers, such as prostate cancer. While it's not very common, radiation therapy, including targeted radiation like Pluvicto, can cause localized swelling or inflammation in the areas where the radiation is delivered.

Swelling may be related to:

Tumor Shrinkage: As the tumor responds to the radiation, it may cause temporary swelling due to the breakdown of cancer cells.

Inflammation: Radiation can lead to inflammation in nearby tissues, leading to swelling in the area being treated.

Fluid Retention: In some cases, radiation therapy can cause fluid retention in the body, contributing to swelling in various parts, including the extremities or face.

It's important to inform your healthcare provider if you notice any swelling or discomfort after receiving Pluvicto treatment. They may recommend ways to manage or reduce swelling, including medications, compression garments, or other interventions.

(From one Libra to another).

Good Luck, Good Health and Good Humor.

j-o-h-n

[Oct18 in reply to j-o-h-n]

Thank you j-o-h-n!!

Good health and good humor to you

[CAMPSOUPS]

From my experience there can be a reaction in bone mets to Pluvicto.

Its inconsistent. May or may not happen and seems to randomly be one or a few out of many bone mets that react.

I was lucky to not have pain. Out of hundred's of bone mets Pluvicto and a bone met in my lower left jaw had an argument and my lower left jaw remained numb for about 6 months after the last infusion lol. I'm grateful that a year after my last Pluvicto infusion my PSA is still going down.

Hopin you get good results from Pluvicto.

[Oct18 in reply to CAMPSOUPS]

Thank you for sharing and I hope your PSA continues to go down and stays down for a long time.