I finished my 40 radiation treatments on Wednesday, 1/22. Started back on 11/21. 23 doses to prostate and whole pelvis, then another 17 to just the prostate.
My PSA had reached 2.72 in early October but dropped to 2.43 in early November (before radiation) then to 2.23 on 12/5 (7 radiation doses in). My RO advised caution in relying on early post-radiation PSA readings, but my urologist had scheduled a test for 1/22 (hours before final 40th dose); it was 0.78.
Still a question about my three bone Mets. After appearing on 6 years of scans, my first PSMA scan in July did not find them. I asked my RO about doing a biopsy on one or more of them. He checked with the clinic's interventional radiologist. After reviewing the scans going back to 2018, that radiologist opined that, while he could biopsy the spots, he thought the yield would be negligible. So there we are.
Lots of discussions to have moving forward.
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dhccpa
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I am not a doctor but I would rather not biopsy anything out of fear to spread the cancer.
If your PSA will drop very low then you will know that the Mets in your bones and elsewhere are sleeping. You could maybe at some point in time repeat the PSMA pet scan or even an MRI to see if there is a bone marrow involvement visible on the MRI. Furthermore if your PSA start going up you could get an FDG pat scan for PSMA negative cancer.
I also had lots of bone metastasis but my medical oncologist professor Richard Epstein wasn't very enthusiastic about a bone biopsy. I believe it is very difficult to get out enough useful material. Therefore better if you don't touch it in order to prevent a possible spread plus you will probably not achieve anything especially because the Mets are not visible on the scans.
Sounds like you still have more to your adventure. Best wishes on it.
When I finished up radiation I waited quite a while before I finally going back to the gym. That was a mistake.
I would encourage you to start back on at least some cardio ( I started by walking in the neighborhood) as soon as you are both physically and mentally capable, then transition into some cardio and weights.
I honestly believe this had made a profound positive difference in my Quality of life.
Again best wishes on your journey. ( I have started calling it the adventure)
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Is ADT and radiation enough?
RO Consult /Radiation or wait for Molecular Tests
Insurance denying coverage for Radiation
starting salvage radiation next week 
Another Old Codger just learning of this site
