Carbogoline treatment

[c1esterase]

I have had advanced prostate cancer for over 20 years. In Feb 2017 I was diagnosed with Prolactinoma. Prolactin level of 17000. PSA at the same started to rise having been held at single figure for years.I started treatment with Carbogoline once a week which was reducing the tumour. I increased the Carboline to twice a week and my increasing PSA was slowed. As I expected but surprised my Oncologist. I would please like as much info on this treatment as possible.

[pjoshea13]

See:

healthunlocked.com/advanced....

"Prolactin & Cabergoline."

-Patrick

[Tall_Allen]

One oncologist I talked to felt that estrogen would also reduce prolactin and there's more evidence that it benefits those with prostate cancer.

[Lilith_lilith]

How old were you when you were first recognized by advanced PC?

[c1esterase in reply to Lilith_lilith]

I was 57

[LearnAll]

Swanson Chasteberry fruit extract (amazon) It is also known as Monk's pepper.

After reading research by Castello et al ,I checked my serum prolactin and it came 9.2 (normal 2 to18).

I am starting Chasteberry fruit extract (see above) to lower Prolactin to below 5. Has anyone tried this natural prolactin lowering berry before going to cabergolin.

Will check prolactin after using this for 8 weeks.

[Shanti1 in reply to LearnAll]

Please let us know what your numbers look like on the retest. A friend of mine has been emailing back and forth with Costello and shared with me the correspondence. He (Dr. Costello) stated that the prolactin had to be brought to zero for this approach to work, similar to the idea that ADT should bring T to <50 (personally I think that is still too high). Maybe lowering prolactin with chaste berry could be helpful, but if someone really wants to turn off prolactin completely, I'm afraid they will need cabergoline.

[LearnAll in reply to Shanti1]

I have not statrted taking the Vitex fruit as I am still trying to figure out if it is worth taking when someone is fully hormone sensitive with PSA 0.3 and T less than 10.

[Shanti1 in reply to LearnAll]

Yeah, I can understand that, one more thing to take! Of note, also in the correspondence, I was privy to with Costello, he stated that the clioquinol and zinc combo was the approach for hormone-sensitive and the cabergoline was for castrate-resistant when the cancer had learned to use prolactin instead of testosterone.

[LearnAll in reply to Shanti1]

Thank you Shanti 1, you solved my dilemmma. So, ionic zinc plus Clioquinol can be taken while hormone sensitive...great...I have to procure clioquinol in near future.

[Shanti1 in reply to LearnAll]

I think you know, use the cream, oral clioquinol is associated with toxicity.

[LearnAll in reply to Shanti1]

Clioquinol cream IS NOT available in USA anymore.

[Shanti1 in reply to LearnAll]

Yes, this is true, you need to either get it compounded by working with a doc or get it overseas.

[kaptank]

Interesting review of this topic by Costello & Franklin Oncology Reviews 2018 v 12 356 "Testosterone, prolactin and Oncogenic regulation of the prostate gland. A new concept: testosterone-independent malignancy is the development of prolactin dependent malignancy! Sorry I have the PDF of this but have no idea where it came from. If PJ or Nal have it please post. Basic thesis is in the title. Potentially important but so far there are only a few case reports. You seem to be another one. Do keep us informed. This has been the subject of interesting discussions.

[c1esterase in reply to kaptank]

Thank you. I am in the UK. Will keep you posted on my research.

[HanswoodRJ]

Hi. I'm in New Zealand and hoping to try the treatment in a few weeks. I have the Cabergoline, Clioquinol and zinc supplements needed. Cheap ( subsidized in NZ?) it seems essential to get the right form of zinc ionophore so it can facilitate zinc transport. I was recently diagnosed with treatment related large cell neuroendocrine PCa. My Dr has contacted Costello to get further info. Welcome to the world of Guinea pigs. Will keep you posted.

[c1esterase in reply to HanswoodRJ]

Thank you for your info. I am in the UK.

[FRTHBST in reply to HanswoodRJ]

Yes, please let us know the effects of your regimen.

[HanswoodRJ in reply to FRTHBST]

Will do. Not sure when I am starting but hopefully during Feb. Target is to take it for 8 weeks.

[vivamais7 in reply to HanswoodRJ]

What about results with Dr. Costello's Protocol?

[kaptank]

This is the Costello & Franklin paper I referred to above.

ncbi.nlm.nih.gov/pubmed/300...

[c1esterase in reply to kaptank]

Thank you.

[tallguy2]

Please

Keep us posted. My urologist wasn’t convinced by this one-off study. No clinical trials underway., either. I will ask my MO this week.

[tallguy2]

I asked my MO about prolactin this week and provided a copy of the articles. “You do not need to be worried about your prolactin levels based on a one-off study.”

[c1esterase in reply to tallguy2]

I am not worried prolactin level. I hope that prolactin helps to cancel out testosterone problem. I have an appointment with my Oncologist in two weeks to discuss my findings. Thank you.

[c1esterase]

My regime has reduced my PSA. Will continue for another 6 months. Does seem to work for me. Not much help from NHS because not a funded treatment for advanced prostate cancer. Will keep you posted. Looks good for me.

[c1esterase in reply to c1esterase]

Will keep going as long Cabergoline is available from my Prolactinoma treatment.

[Shanti1 in reply to c1esterase]

I am happy to hear you have found something that may be working for you! Could you share with us your PSA numbers and how they changed relative to the cabergoline? Thank you

[c1esterase in reply to Shanti1]

Up to12/2016 PSA single figures

Feb2017 Prolactinoma 500mcgm once a week

May 2017 PSA 12

Oct 2019 PSA 34

Nov 2019 Cabergoline up to twice a week

Jan 2020 PSA36

Definite slowing of increase.

Will keep you posted.

[Rooked in reply to c1esterase]

Try adding zinc gluconate 50mg daily to see if that helps. That is if you can.

[c1esterase in reply to Rooked]

Will try to find out. Thank you.

[Shanti1 in reply to c1esterase]

Hi- thank you for posting. We all learn from each other. A friend of mine has been emailing back and forth with Costello and shared with me the correspondence. He (Dr. Costello) stated that the prolactin had to be brought to zero for this approach to work. If you haven't done so already, you may want to monitor your prolactin and and move it down toward the very low side of that range to see if you can get even better results. Also in the work by Costello (see papers linked to in this thread) is the use of a cream called clioquinol which works synergistically with zinc and could be considered as an add on to the cabergoline. Wishing you the very best.

[c1esterase in reply to Shanti1]

Thank you for interest etc. Much appreciated. I would like to communicate with Dr Costello. Do you have an email address ? All the best to you too. Will keep you posted.

[Shanti1 in reply to c1esterase]

You can find contact info for Dr. Costello on the U. of M website: dental.umaryland.edu/ods/fa....

Here are links to his work that would be good to look at:

ncbi.nlm.nih.gov/pmc/articl...

ncbi.nlm.nih.gov/pubmed/312...

ncbi.nlm.nih.gov/pmc/articl...

[c1esterase in reply to Shanti1]

Thank you very much. Will see what I can find out.

[c1esterase]

My PSA has gone from 36 to 31. Carbogoline regimen seems to apply to my particular case of advanced PC. However NHS not interested because no clinical trials and not funded by NHS. Unbelievable !! Where do I go now ????

[Hidden in reply to c1esterase]

How are you doing? Are you taking also the zinc (maybe ionic zinc)?