Seeking Advice on Second-Line Treatment for Small Cell Prostate Cancer

[Andy2025]

My father has been diagnosed with small cell prostate cancer. He completed six cycles of cisplatin and etoposide, followed by radiation, in July 2024. A PET scan in June showed a significant reduction in prostate size and cancer activity. Unfortunately, the December PET scan revealed a substantial increase in cancer activity.

There is a possibility of metastasis to the lungs (though it could be an infection), and lymph nodes that had previously cleared up have flared up again.

Are there any second-line treatments available for this type of cancer? Has anyone gone through something similar or have any insights to share?

His treatment is currently being managed in Chennai, India. Any advice or thoughts would be greatly appreciated.

Thank you!

[GP24]

There is a subgroup of neuroendocrine PCa patients which has PSMA positive cancer. Should a PSMA PET/CT reveal this is the case for your father, he could try a Pluvicto therapy. Neuroendocrine PCa patients often have a BRCA mutation which would indicate that Olaparib could help.

[j-o-h-n]

Greetings Andy2025,

During a CT scan, the doctor recently discovered nodules on my lungs and had me redo the CT scan 4 months later and determined they were from infection (I was overjoyed with the new scan).

I also had a case of Lung metastases due to a melanoma which was treated with Keytruda (immunotherapy) and it worked (about 6/7 years ago.

Give your dear Dad our best wishes Keep posting!!!

Good Luck, Good Health and Good Humor.

j-o-h-n

[antisocialsocialwrkr]

Hi, my dad is in the same boat..same chemo and diagnosis. Those chemos you mentioned worked short term but like you mentioned, it’s aggressive and cancer grew back quickly in his liver. He also had a spot show on his lungs after and it ended up being nothing. Apparently that happens often and can be from infection among other things.

My dad’s next move was a clinical trial. He is no longer on it but scans have been stable under cabazitaxel and carboplatin regimen. He is still here with us 1.7 years later after small cell diagnosis! There is hope. I am sorry you and your family are going through this.

[Andy2025 in reply to antisocialsocialwrkr]

Thank you for sharing your dad’s journey.its encouraging to hear about his stability 1.7 years later. Is his current chemo part of a second-line treatment? Wishing him continued strength.