Question in mid-radiation

[dhccpa]

I just finished Day 11 of 40 days of IMRT.

I meet with MO on Thursday. I've been on Lupron only since 2018 and I know we'll discuss the topic of adding Zytiga, Xtandi, Darolutamide, of Erleada.

Is it OK to add any of those while I'm early into radiation?

[aloha_spaceman]

I actually started my ADT about 30 days prior to radiation. My understanding from my care team is that there is a synergistic effect.

[dhccpa in reply to aloha_spaceman]

Thanks, but I was asking about the second-level hormone choices, as listed in my post. I'm already on Lupron, have been since 11/2018.

Did you start either Zytiga or Xtandi or Nubeqa or Erleada before radiation?

[aloha_spaceman in reply to dhccpa]

Sorry I wasn’t clear. I started Lupron and Xtandi about a month before radiation.

[dhccpa in reply to aloha_spaceman]

Thanks!

[treedown]

We are all different but I actually had to stop Zytiga during my radiation due to severe drop in lymphocytes. Started again after radiation was over and at a reduced dosage. Lymphocytes recovered after a year or two.

[dhccpa in reply to treedown]

Thanks

[dhccpa]

Thanks

[treedown]

No that's just you, your very different, very very different 🙂

[treedown]

Depends on what day you ask me, today it's bad.

[j-o-h-n]

They say "Being different, makes a difference."

Good Luck, Good Health and Good Humor.

j-o-h-n

[AlmostnoHope]

Xtandi intermittently I say. I don't like Zytiga. I think personally that it's just a bridge to CRPC.

[dhccpa in reply to AlmostnoHope]

What makes you say that about Zytiga? I haven't heard that specifically about it.

[JazzAM]

My stage 4b pc started in early 2023 with a psa level 1500! Thought it was just old age joint pain. Boy was I wrong. Did the degarelix lupron and xtandi routine and worked well for over a year pain gone but tired of course. That brought the psa down to the 300 level then due to psa rises I added docetaxel. The chemo started my short term disability at work and wiped my butt so now after 8 rounds I stopped that. In retirement now I’m restarting lupron and xtandi to see if it will in the short term get me to maybe psa 4. Of course already having one psma-ct scan the next step if pain returns and psa heads up again that will be the time for me to venture into another psma scan and start Pluvicto. Atleast for me chemo side effects just caused too many side effects….lost all my hair and fingernails. The worst was the epiphora on the eye ducts besides the exhaustion. So now I try to limit my number of drugs all at once so I can isolate what drugs cause the worst side effects. Once in a blue moon I would get horrible back pain but a tramadol got rid of it. Someday I may need daily opiates but for now I stick to legal daily doses of delta 9 since I’m now retired. Lost so much weight that helps with the loss of appetite as my tastebuds come back after the chemo stole them! Anyways that’s my story and I’m sticking to it for now. Cancer is a full time patient research job now. What works for one may not work for another in this game of chess🎅Best of luck to all and Merry Christmas to all!