NOTE: What could have been a sober discussion has broken down into political sniping, irrelevant to our advanced prostate cancer purpose. For that reason alone, replies to this post have been turned off.
Please note that this post was created by a poster on his/her first day on our community. The poster mentions that they read about good results, but has not included any links or references. I have failed to find any human studies that suggest invermectin as a helpful medication for advanced stage prostate cancer. If you are interested in taking it, FIRST, ask one or more urology focused oncologists. Everything you swallow has an opportunity to cause more harm than good.
ORIGINAL POST:
I read about so many good results of desperate cancer patients being cured after using Ivermectin. What are your thoughts on this treatment? Yours sincerely, George Joubert
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GeoPam28
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kInda funny how “all these good results” are one google search away and yet the forum for advanced prostate cancer is not receiving any threads. At least not for the year and a half I have read it regularly. I mean. All these good results, you would think one of the thousands of people with actual advanced cancer, that have posting rights to healthunlocked, would have documented their ivermectin based remission? are they gatekeeping a cure?
I mean, site/wide ivermectin is helpfully tagged. Here is the tag and topic list. In all health forums. Can you find a remission story here? I cannot. Maybe there is one. There should be dozens.
Dozens , maybe more …. desperate aPCa patients here have tried ivermectin. It’s an old topic that was hashed over several years ago. Not one single guy that tried it has ever claimed it helped them at all, let alone cured them. Some here hate it because they had aPCa friends that tried it out of desperation and are dead.
Well, as far as I know, there are TWO types of Ivermectin; one IS used for horses/animals, BUT the other type has been used in humans for years to disrupt viruses/cell division. Is it all about $$$, or does it have ant efficacy vs PCa? I don’t know.
Alternative treatments as in instead of SOC, or in addition to SOC?
Firstly I haven't seen anything to suggest that trying it is detrimental.
I think a decent approach to any treatment is to research as much as you can out of it, and make your decisions on the best evidense you've got. I personally think its important to understand as much as possible. Will you understand everything? I doubt it, but the more you understand the better your chances of making a decision thats right for you - no one else. This should be regarldless of what other people say. It's your body, your disease and you control ANY treatments at the end of the day.
The best evidense I think you're going to find is RCT's. These are often referred to as the 'gold standard'. Does that mean that theyre infallible? Nope. There are well recognised issues with them, but they are the best evisence you're going to find available. By considering these, I suggest to you that it will increase the probability of finding information that is correct. Again, it doesn't mean that theyre infallible, but it is with a high probably that it's going to be the best you can get.
If you look at evidence based on observation studies, questionaires, meta data studies, database lookups... the list goes on - IMO these are better suited for hypothesis generation. For me personally I would avoid these and rely on better quality data if possible.
So, would I consider Ivermectin as a relatively safe punt? Sure, why not?
Would I replace treatments with better evidence? Nope, I think its a bad idea. For me I'd go with the probabilities plan.
But if you've read something that suggests to you the contrary, and you understand it and are happy with it, go for it.
I've never read anything to suggest that that's the case. If it was some sort of solution I think you'd be reading a LOT of success stories on this site. But just remember that everyone is a unique N=1 case.
Ivermectin is an anti parasitic used to treat a variety of parasitic diseases in humans for years. Ivermectin shows excellent efficacy against conventional chemotherapy drug/resistant cancer cells and reveals multi drug resistance. I researched many sources and find it to be a valid drug and not a snake oil . I think someone misinformed you
While I'm not advocating taking Ivermectin to treat my cancer, plenty of medications are prescribed for off label use, which by definition means there aren't clinical trials supporting it use.
That's not a definition of"off-label." Off-label means that the FDA has not approved that indication. That usually occurs when a drug is old or generic but has proven benefit in a clinical trial.
One should never take any medication that has not been clinically tried.
There are no clinical trial results.It is you who are misinformed.
I said I don't support using it but if there's an oncologist prescribing it for prostate cancer, it use is off label, which by definition means there's no clinical trial data approving it's use. Otherwise it would be on label.
And trials that are FDA approved are on the medication label. Hence, if a doctor uses medication for an non approved use, it's called off-label. The concept isn't that complicated.
Those who deny its effectiveness are simply brainwashed and some are Big Pharma advocates who fight any non pharmaceutical products no matter how successful they are.
In one hundred years what did Big Pharma to fight cancer? The same old dangerous Chemotherapy and radiotherapy …. Let’s wait for the Russian Cancer Vaccination coming this new year. At least Russians don’t have big sharks like we do and our biggest sharks at Big Pharma won’t eat them.
To Tall Allen and MoonRocket (also Lrv44221 - to you I tip my hat)
It pains me to see two people of good faith at odds over misapprehended meanings. It wastes bandwidth, does not advance either person's case, generates rancor and obscures the truth.
At the risk of being accused of taking things out of context, here are some excerpts from the web site cancer.gov/about-cancer/tre... cited by MoonRocket.
"Research studies find new uses for drugs that are already approved. The results of research studies are published in medical journals and shared in the medical community. Doctors then adopt the new use and it may become an accepted and widely-used treatment for a different cancer, even if the FDA has not approved the drug for that use."
Ivermectin is already approved for some uses in humans? If so, using it for cancer would meet the definition of "off-label". Requiring clinical trials before using it (whether you call it "off-label" or quackery) does not seem to be a part of the definition of off-label, nor prevent physicians from prescribing it. Tall Allen, if I am wrong about this, please show me where I have gone astray in my reading of the site.
As far as ivermectin is concerned, I would consider using it myself since there does not seem to be a downside to its use. My PSA currently is successfully suppressed by ADT, but ADT alone is not curative. I have seen first-person testimonials (Some are by medical doctors, by the way.) of its effectiveness, though. These testimonials are compelling, but not yet convincing.
By the way, my PSA (currently below 0.014 ng/mL) has been suppressed by another off-label ADT. One shown to be equally effective as orchiectomy in the 1940s, but not so safe. (Killed about one-third of the patients.) But trans-dermal administration has now been shown in many clinical trials to be safe AND effective in the past few decades. It is used to treat other conditions, but not FDA-approved for prostate cancer. Getting approval is fairly expensive and since this drug is not easily patentable, other (more expensive and presumably profitable) drugs have been submitted for and received FDA approval. But those many clinical trials I can cite show this is as effective and as safe as Lupron and my own "clinical trial of one" has shown that this drug suppressed my testosterone and PSA every bit as quickly and deeply as Orgovyx. And my four of my deleterious side effects from the on-label were abated (three completely and one partially) by the off-label drug. A couple of adverse side effects were introduced, one manageable with diet and the other merely cosmetic.
But as good as it is, it is not known to be curative. If ivermectin might be, I may consider it. (But, anyone, please do not read anything more into that last sentence than there actually is in the words.)
Hi Lost_Sheep - you certainly don't sound like a lost sheep - And many thanks for your helpful and gentle post. - I hope it's okay to ask - I'm curious about the off-label ADT you mention in your post - would you be comfortable disclosing what it is? Many thanks and all the best.
My guess is estradiol delivered by external patch - either high dose as replacement ADT ( per PATCH trial ) or low dose in conjunction with standard ADT.
Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells. This may be related to the regulation of multiple signaling pathways by ivermectin through PAK1 kinase. On the other hand, ivermectin promotes programmed cancer cell death, including apoptosis, autophagy and pyroptosis. Ivermectin induces apoptosis and autophagy is mutually regulated. Interestingly, ivermectin can also inhibit tumor stem cells and reverse multidrug resistance and exerts the optimal effect when used in combination with other chemotherapy drugs.
Hi! May I ask if you are a doctor or pharmacist! I used Ivermectin 12 mg a day for 2 months and I cannot vouch that Ivermectin was the result of my PSA coming down from 560 to 5.15. Regards George
Ivermectin is cheap. What have you got to lose. Take the SoC and add 24mg Ivermectin a day. I have more energy since taking that. Real or imagined, all the same to me.
I don’t advocate for using drugs for other than their described purpose, but ivermectin did win a noble prize for effectively treating humans with many diseases, like parasites (someone tried it on humans). Researchers find new treatments with many drugs that have been around for other purposes all the time. One must have an open mind when it comes to new treatments and methodologies and unfortunately sometimes we have to be the guinea pigs in these new treatments using older drugs or new drugs and combinations thereof.
NOTE: What could have been a sober discussion has broken down into political sniping, irrelevant to our advanced prostate cancer purpose. For that reason alone, replies to this post have been turned off.
Please note that this post was created by a poster on his/her first day on our community. The poster mentions that they read about good results, but has not included any links or references. I have failed to find any human studies that suggest invermectin as a helpful medication for advanced stage prostate cancer. If you are interested in taking it, FIRST, ask one or more urology focused oncologists. Everything you swallow has an opportunity to cause more harm than good.
The ability to reply to this post has been turned off.
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- And many thanks for your helpful and gentle post. - I hope it's okay to ask - I'm curious about the off-label ADT you mention in your post - would you be comfortable disclosing what it is? Many thanks and all the best.
Off Topic, How to find postings by a particular person 
Olaparib 
Sorry to be a party pooper
Alternative vs modern medicine 
