Transformer Trial-- Please share information regarding BAT.

[SViking]

After eight different attempts at taming the beast over the last five years I finally went castrate resistant two years ago. Then came failure with Eclipse Trial (Pluvicto), Provenge and two more rounds of SBRT until recently when RO said no more radiation. Hemoglobin is 10.5 for last several years. PSA is still relatively low but rising fast. Mono Xtandi was also not working with brutal side effects so we switched to Nubeqa last month with no side effects. But also ineffective.

MO approved Transformer Trial which started a week ago with 400 mg shot of testosterone and two more scheduled every 28 days while requiring to stay on Orgovyx. (cancelled Nubeqa while on trial) Within 24 hours I was sporting wood all night...BUT had an immediate energy/strength decline and severe loss of appetite, Normally while on testosterone a decade ago appetite went through the roof while strength and stamina increased.

WTF? Please share thoughts, experiences and concerns.

[Tall_Allen]

Great to hear!

[SViking in reply to Tall_Allen]

Since I basically had a poor reaction to the testosterone injection. Why is that great to hear?

[Tall_Allen in reply to SViking]

Libido returned, strength will follow in time.

[Cenerus]

When did the fatigue and loss of appetite start? Was it literally right away, or did it take a few days to become noticeable?

[Cenerus in reply to Cenerus]

I did a bit of research and found that testosterone therapy will result in fatigue and loss of appetite. It’s counterintuitive but apparently common.

[SViking in reply to Cenerus]

it took a few days to become noticeable. But it’s quite pronounced now. Do you know if this fades after a while?

[Cenerus in reply to SViking]

Yes it’s supposed to fade after a while once your body adjusts to the high level of testosterone and the other secondary hormones and byproducts of the high serum testosterone level.

[addicted2cycling in reply to SViking]

SViking, since 2015 I have been ON/OFF/ON/OFF/ON/OFF 200mg Cypionate biweekly injections watching PSA and T levels closely. Following the injection I've tested at T ≥ 1,600ng/dL with very little changes physically/mentally.

Suggest you check both PSA and T at least once a month. If I were you and in your situation I would check twice a month even though it's excessive.

Good LUCK 👍👍

[NecessarilySo]

That's very low hemoglobin at 10.5. Mine is below normal at 13,5. It leads to iron deficiency anemia. I'm taking vitamin B12 twice a day lately and iron supplements twice weekly. The anemia seems gradually better but I haven't tested for two months. It could explain your energy decline. Check your blood iron level.

[gsun]

The TRANSFORMER trial looks good. BAT resensitizes the body to enzelutimide.

[j-o-h-n]

Within 24 hours I was sporting wood all night. To quote an old spiritual "Free at last, free at last thank God almighty I'm free at last."

Good Luck, Good Health and Good Humor.

j-o-h-n