when to take abiraterone….: on what... - Advanced Prostate...

Advanced Prostate Cancer

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when to take abiraterone….

Tommyj2 profile image
51 Replies

on what schedule are most folks taking their abiraterone……I thought I had it right initially but now a pharmacist is telling me I should wait 2 hours after taking Abi before I eat or take anything else….. thought 2 hours/1 hour was the general rule…….i was taking Abi upon awakening…..then at least an hour later the rest of my meds with a small amount of food……

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51 Replies
Huzzah1 profile image
Huzzah1

Take on an empty stomach - 1 hour before eating. Or - 2 hours after you eat.

Tommyj2 profile image
Tommyj2 in reply toHuzzah1

Thanks…that’s what I had been doing….

Pjford profile image
Pjford in reply toHuzzah1

That’s what I do

fireandice123 profile image
fireandice123

I take mine when I inevitably get up to pee, usually around 2 am.

MahlerFan profile image
MahlerFan in reply tofireandice123

Good idea! Rising at least an hour before normal difficult for me (sleep is medicine, too).

ulfhbg profile image
ulfhbg

Hi !

Wait to eat at least 1 hour after taking Abiraterone. After have eaten, wait at least 2 hours before taking Abiraterone.

Then i suppose it’s up to you if you want to wait 2 hours or etc.

Tommyj2 profile image
Tommyj2 in reply toulfhbg

Thanks…that’s how I had been taking it.

Tommyj2 profile image
Tommyj2 in reply toulfhbg

that’s what I was led to believe initially….and why I am asking the question…..pharmacist at bio-plus pharmacy says otherwise….. I’m going to stay with the 2 and 1 protocol.

6357axbz profile image
6357axbz

I’ve been taking for 6 years and finally arrived at sometime between 12 and 2 AM. No need to worry about food then, at least for me.

petabyte profile image
petabyte in reply to6357axbz

Are you sure 😎

Far side
petabyte profile image
petabyte

I was doing similar but waiting 2 hours to be safe (1 hour is what is written).

Today I am doing them all together orgovyx, abi and pred at 06:00, no food but plenty of water. May not work for everyone but I was fine today.

I wrote a post about taking pred. recently (yesterday?)

On waking for pred aligns better with natural cortisol levels.

Tommyj2 profile image
Tommyj2 in reply topetabyte

I recall that post….something to consider.

85236442968 profile image
85236442968 in reply topetabyte

petabyte

From the beginning, I have taken the Abi/Pred right after a get up in the morning, then by the time I am done in the shower and shave and such, then make coffee, an hour has passed.

No real issues other than the regular side effects.

petabyte profile image
petabyte

btw micronized abi exists (Yonsa) that can be taken with food. Dose is 500mg typically with 4mg methylprednisolone.

Tommyj2 profile image
Tommyj2 in reply topetabyte

Abi in its regular form is working well for me and I don’t have to pay for it right now……so I’m not going to make any changes…..but……half the dosage of Abi and pred sounds appealing.

petabyte profile image
petabyte

In theory you absorb the same amount so unlikely to make any difference except timing and one less pill to swallow.

Huzzah1 profile image
Huzzah1

I'm going to add 1 more thing. If you lay on your right side, drugs will be absorbed into your system much faster than if you lay on your left side.

engineering.jhu.edu/magazin....

TylexGP profile image
TylexGP

When I was on Abi for two years;I did exactly what you are doing with no issues.

Chrisbaird profile image
Chrisbaird

take it 2 hours before eating prednisone tablet with food but have found must take a large amount of water with tablet or can affect stomach or liver 3x times I had very bad stomach upsets

Tommyj2 profile image
Tommyj2 in reply toChrisbaird

Good to know…..I ,fortunately, tolerate it well.

youngigor profile image
youngigor

On holiday now but when taking AA preferred 25 % of regular dose with healthy lunch. Amount of prednisone was 100 % of regular dose (because the AA in blood was the same with this approach)Cost was not a factor. Primary motive was to avoid some discomfort with breakfast when taking it at 0500 or 0600 hrs.

Tommyj2 profile image
Tommyj2 in reply toyoungigor

Thank you for the response…..

TommyCarz2 profile image
TommyCarz2

ONE hour BEFORE Solid Food. OR, TWO hours AFTER. The Pharmacist is WRONG. When I doubt, read the label or visit the manufacturers website

Tommyj2 profile image
Tommyj2 in reply toTommyCarz2

I know the pharmacist is wrong…..that’s why I double checked it with the group……there ARE a few people who also take it incorrectly.

Apisdorsata profile image
Apisdorsata

I tried taking 1000 mg on an empty stomach but it caused too much nausea so I tried 250 mg with breakfast. It was not enough. Now I take 500 mg with a meal and it works fine. My meal is 300-400 calories and 8-10 grams fat.

Tommyj2 profile image
Tommyj2 in reply toApisdorsata

Thank you……

DesertDaisy profile image
DesertDaisy

My husband takes his abi as soon as he gets up in the morning and then waits at least an hour before eating. He takes his prednisone with dinner.

Tommyj2 profile image
Tommyj2 in reply toDesertDaisy

Good to know…..TY

wpeebles profile image
wpeebles

My pharmacist explained that since Abbie can make you tired after you take it, why wouldn't you take it just before you go to bed. Made sense to me so I stop eating around 8:30PM and take the pills around 11PM. If I want to go to bed earlier, I just stop eating earlier.

Tommyj2 profile image
Tommyj2 in reply towpeebles

Thank you…..

Docker53 profile image
Docker53

My husband's pharmacist told him to take 2 hrs after a meal and he also recommended to take them at night because one of the side effects are fatigue and that is why hubby takes it before bed around 10 pm.

Tommyj2 profile image
Tommyj2 in reply toDocker53

Thank you for the info.

petabyte profile image
petabyte in reply toDocker53

I was under the impression that tiredness is a overall side effect that is independent of the dosing schedule but everyone is different so if you get it after a dose nighttime would be a good idea.

Conlig1940 profile image
Conlig1940

I'm curious . Has anyone on this forum heard of a patient being given " IVERMERTIN " for prostate cancer ?

Tommyj2 profile image
Tommyj2 in reply toConlig1940

I think you mean ivermectin…..and,yes, there are many posts here re: this drug…..but….i haven’t heard of it being physician prescribed.

Conlig1940 profile image
Conlig1940 in reply toTommyj2

I have an associate in Toronto who is taking it . He has been on Active Surveillance for 5 plus years . It is not physician prescribed , as you indicated . He maintains it works .

Any comments from other users you can pass along ?

lokibear0803 profile image
lokibear0803

there has been some confusion on this point, and to make things worse - the label on some ABI bottles also states it incorrectly. It's 1 hour before and two hours after.

And if you think about it, that makes sense. You're trying to not digest both the ABI and food at same time. If you wait for 2 hrs after eating, that minimizes the risk.

The ABI itself is metabolized more quickly than food, so that's why it's only 1 hr before taking the ABI.

So using common sense here is how I remember the protocol.

Tommyj2 profile image
Tommyj2 in reply tolokibear0803

You are incorrect…..the manufacturers site clearly states 2 hours BEFORE and one hour AFTER……

dk73 profile image
dk73

When he first started in 2020, he’d get up at 5:30, take 4 pills, then eat breakfast at 7:30 plus the prednisone. Some mornings if he woke up at 4:30 am, he would do it then

But right now he’s taking only one tab with low-fat breakfast. It’s a stopgap move, had to stop chemo to do hyperbaric oxygen treatments for the next 2 months

VictoryPC profile image
VictoryPC

The gateway drug to CRPC in my opinion and experience. Enough said.

Tommyj2 profile image
Tommyj2 in reply toVictoryPC

Not enough said…..why would you say this?

AlmostnoHope profile image
AlmostnoHope in reply toTommyj2

That stuff has led to CRPC in everybody who has taken it that I know of.

mababa profile image
mababa

Personally, I wouldn’t worry too much about that. We’re all taking so many meds that trying to figure out optimal timing for eating is a bit extreme. I’m happy just to have my Apple Watch (thank you, Amore) remind me to take the damn pills morning and evening. Look, your meds, over weeks and months, average out over many different conditions in your life, including during travel. Just be sure to take them and while you focus on maintaining your QOL. :) (My Abi is working well and doesn’t seem to care much about what or when I eat.)

petabyte profile image
petabyte in reply tomababa

+1 on the smartwatch. I treated myself to an ultra 2 recently and it is great for medication and exercise.

And agree completely on QOL.

Godsheal profile image
Godsheal

my routine… take Abi 6:30 am, followed by I/2 dropper of CBD @ 7:00, eat breakfast between 7:30 & 8:00, with prednisone after eating. Works well with minimal side effects. Going on 7 years Mpca. And PSA still undetectable. Living life and trusting God. 🙏

Tommyj2 profile image
Tommyj2 in reply toGodsheal

Still castrate resistant after 7 years?

Churchman123 profile image
Churchman123

I take my Abiraterone last thing at night at least 2 hours after my last meal. Have survived for nearly 4 years now.

Tuckerhoo profile image
Tuckerhoo

72 year old male, Gleason 8 - when I started taking abi in Feb 2024, I was NOT adhering to the 2 hour protocol (no food 2 hours before & after taking daily dosage of abi) - I was experiencing extreme fatigue and had what I would call vertigo several times - starting in July 2024, I was taking my daily abi during my 6 AM visit to the bathroom - this assured 2 hours before AND I never eat before 10 AM - so the protocol was adhered to - since that July change, the fatigue has gotten much better AND no more vertigo - GOOD LUCK!

Tommyj2 profile image
Tommyj2 in reply toTuckerhoo

The vertigo you describe….are you feeling dizzy upon getting up…or quezy looking down from heights?

Tuckerhoo profile image
Tuckerhoo

It was just a few time but very unnerving. I would get up in the morning and practically fall over in taking a few steps. It had nothing to do with heights

Tommyj2 profile image
Tommyj2

sure it wasn’t postural hypotension?

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