doctor has changed ( abiraterone + prednisolone) to ( Xtandi). How justified and productive is this substitution?

[Zavulon1945]

Good afternoon, community! I am new here and thank God for this opportunity to be among you on this chat. Three years ago I was diagnosed with aggressive prostate cancer. PSA =13.0. Prior to surgery the skeleton was clear. With the surgery it took 4 months. Result - post-op PSA =16.0 and metastasis to bone. Gleason 9. Had chemo. 5 sessions. Then three radiation treatments of 14 sessions each in the pelvis and ribs. Last radiation was in May of this year. Then abiraterone + prednisolone. In addition, once a quarter I received and still receive leupron in the abdomen and once a month Hgeva. For 15 months PSA was below 0.03. Recent tests showed a slight increase first to 0.7, then to 0.24. And the day before yesterday already a significant 0.67. Due to this my doctor has changed ( abiraterone + prednisolone) to ( Xtandi). I would like to know from the experienced community, how justified and productive is this substitution? And one more question. If there are any German patients in the chat, I would like to ask them to give me the name of a good oncologist practicing in Baden. I live in the city of Baden-Baden and for three years have not found a good oncologist. I will be very grateful for any answer. Health to all and more joy in every day.

Willy.

[Mascouche]

Can't know if Xtandi will work better for you against your rising PSA than Abiraterone/Prednisone until you try it.

But for me personally, I find that the side-effects that I am getting with Xtandi are milder versions than what I used to get when I was taking Abiraterone/Prednisone. It's still no picnic but its less severe and I hope that will be the case for you as well.

Best of luck!

[TomMaloney in reply to Mascouche]

I like the switch, I went through it. I have Gleason 9 and am terminal, but Xtandi did help for a while. If Tall_Allen makes a reply, believe him.

[Zavulon1945 in reply to TomMaloney]

Xtandi helped you for a while. May I ask what you did after Xandi?

[Prelki]

I don’t know if this is an option for you, but you may want to consider or read about apalutamide (Erleada) as posted 5 hours ago by Maxone73 above. Interesting results. Good luck to you.

[Tall_Allen]

It will work for a time, but usually not for long. Enzalutamide+docetaxel may work longer than enzalutamide alone, as in this trial:

prostatecancer.news/2022/10...

[gsun]

Too bad you had RP. You were metastatic all along; the scans just missed it. With a PSA of 13, that should be a clue.

[Zavulon1945 in reply to gsun]

Not necessarily. A good friend of mine with a PSA around 30.0 has no metastases. He's been tested multiple times.

[j-o-h-n]

Greetings Zavulon1945,

I Think it would be a good idea to copy and paste your above post (which is in English) to your BIO.

Привет Завулон1945,

Я думаю, было бы неплохо скопировать и вставить ваш пост выше (на английском языке) в свою биографию.

Good Luck, Good Health and Good Humor.

j-o-h-n

[Zavulon1945 in reply to j-o-h-n]

Ok

[j-o-h-n]

Thank you, in the future it will help you and help us too.

Good Luck, Good Health and Good Humor.

j-o-h-n