Amphicrine PCa

[Fonske]

Hello Fellow Warriors 🙂

In March 2024, I was diagnosed with a de novo Amphicrine Prostate Cancer (sometimes referred to as AMPC). I started right away with the triplet therapy: ADT, ARPI and 6 times Docetaxel. Currently still on hormone drugs but Docetaxel has been stopped. Some bone mets detected but organs seem to have been spared.

Joining the battle with all of you !!!

🥊🥊🥊

Last update: PSA still declining. Follow-up bone scan and CT scan planned for end November

🤞🤞🤞

[NickJoy]

Hi P of B,

I came across this group recently which is interesting because I had only seen research on DLL3 theranostatics coming out of the US previously.

It is pre clinical but worth keeping an eye on for the neuroendocrine bit of the prostate cancer. Hopefully they will get to trial soon and that it will be in Europe and the US.

The relevant one is the second down.

molecularpartners.com/pipel...

[Fonske in reply to NickJoy]

Thanks mate for the tip. I'll have a closer look at this.

I came across this link about a very recent article "Promising therapy for neuroendocrine prostate cancer: current status and future directions" ➡️ ncbi.nlm.nih.gov/pmc/articl...

[Tall_Allen]

You might be eligible for the following clinical trial that has sites in France and Spain:

clinicaltrials.gov/study/NC...

[Fonske in reply to Tall_Allen]

Thanks mate for the tip. Not sure if I would be eligible for this since my cancer is still hormone-sensitive and I am crossing fingers that it remains in the current stage as long as possible.

[Tall_Allen in reply to Fonske]

I think they tailor it to the type of PCa you have. It seems ideal for amphicrine.

[Fonske in reply to Tall_Allen]

You are right Allen since I read: "Prostate adenocarcinoma with molecular features of neuroendocrine differentiated cancer (e.g., 2 of the following 3: PTEN, TP53, or RB loss)".

I'll have to check with my doctor since I do not have all the details about my case.

Many thanks anyway 👍👍👍

[Kaliber]

welcome brother.

❤️❤️❤️