Olaparib May Be Effective Without Hormone Therapy in Some Men With Biochemically Recurrent Prostate Cancer

[street-air]

quite a large sub group of men with recurrent prostate cancer were able to put off psa rises and put off mets developing and reduce psa with no hornone treatment just Olaparib - LYNPARZA

in short, the responders, who can be tested by gene typing, had median time of almost 4 years without adt vs the non responders who only managed 12 months - AFTER recurrence. One of the gene types is BRCA.

ascopost.com/news/august-20...

[GP24]

Olaparib monotherapy is very effective for metastatic castration-resistant prostate cancer. ascopubs.org/doi/full/10.12... I see no reason why it should not be effective for hormone sensitive prostate cancer patients, provided a BRCA mutation has been determined. I think you can remove the "may be" in the headline of the report. However, Olaparib has no FDA approval for hormone sensitive prostate cancer patients yet.

[allmo]

This PARP inhibitor study regards Biochemical Recurrence (BCR) stage. The next study should be combination therapy, Parp + the standard (EMBARK study) for high risk BCR, double hormone blockade (ADT {Lupron} + ARSI{Enzalutamid}) vs. double hormone therapy in the control arm.

[muttonman]

I'm BRCA2 and this is good and bad news. I'm on a Facebook group for the drug and 90% of the women are beyond miserable. That being said, I'm thankfull that I got the blood test from the beginning.

[street-air in reply to muttonman]

the more serious side effects sound brutal