Why are Denusomab doses so differently prescribed ?

[Tinkudi]

Dad , 83 has osteoporosis in some areas like femur ( not hips ). Also has many bone mets.

One MO prescribed Denusomab 60 mg to take once in 6 months. Another MO wrote 120 mg to take every month !

Also on this board I see people taking varying doses and frequencies.

Any thoughts ?

[85745]

Could it be based on body weight or age , or maybe the bone density.

[RyderLake2]

Hello,

Denosumab in the lower doses is called Prolia and is taken every six months. A 60 mg dose every six months is what I have been on for the past ten years. That is a preventative or maintenance dose to prevent osteoporosis or any possible skeletal related event (SRE). In the higher doses denosumab is called Xgeva and may be taken more frequently. Hope that helps.

[Tinkudi]

Tall_Allen request you to please give your opinion on this. 🙏🏻

[TeleGuy]

My understanding is that the Prolia dosing is used in HSPC and Xgeva in CRPC. That has been my doc’s plan anyway. She said that every three months with Xgeva is not inferior to monthly so we do my ADT and Xgeva on the same schedule.

[Tinkudi in reply to TeleGuy]

Thanks so you do 120 mg Denusomab every 3 months ? Are you castrate resistant ?

[dhccpa in reply to Tinkudi]

120 mg every three months is my dose. Has been since Jan 2020, but we took a year off from mid-2022 to mid-2023.

[Tinkudi in reply to dhccpa]

Do you have osteoporosis and bone mets ?

[dhccpa in reply to Tinkudi]

I'll be due for a bone density scan. The last was in Sept. 2022. At that time I had no osteoporosis or osteopenia, although the scan supposedly showed 2% deterioration from my first bone density scan done in Sept. 2020.

[Tinkudi in reply to dhccpa]

can’t understand why different doses are prescribed. I wish tall Allen responds but he does not

[TeleGuy in reply to Tinkudi]

Yes to both. And I should add that I do a DEXA scan every two years to confirm that I need it.

[vintage42 in reply to TeleGuy]

"... Prolia dosing is used in HSPC and Xgeva in CRPC... we do my ADT and Xgeva on the same schedule." So you are using Xgeva because you are CR, and are taking ADT even though you are CR?

[TeleGuy in reply to vintage42]

Yes to both. Castrate resistance means that your cancer cells are even more sensitive to testosterone, so you must continue ADT.

[dhccpa]

Excellent question!

[j-o-h-n]

Depends if the drug is on sale.....

Good Luck, Good Health and Good Humor.

j-o-h-n