New drug combination attacks prostate cancer on two fronts to keep men healthy for longer

[dexy1234]

icr.ac.uk/news-archive/new-...

Men with particularly aggressive prostate cancers can be treated more effectively by combining an existing targeted medicine, abiraterone, with a new experimental drug to block two of cancer’s growth signals at once, a major new trial shows

[Schwah]

Good news. It appears to onlyApply however to a certain subset of men with PC, right?

Schwah

[pjoshea13]

"In the 521 (47%) patients who had tumours with PTEN loss by immunohistochemistry (261 in the placebo–abiraterone group and 260 in the ipatasertib–abiraterone group), median radiographical progression-free survival was 16·5 months (95% CI 13·9–17·0) in the placebo–abiraterone group and 18·5 months (16·3–22·1) in the ipatasertib–abiraterone group (hazard ratio [HR] 0·77 [95% CI 0·61–0·98]; p=0·034; significant at α=0·04).

"In the intention-to-treat population, median progression-free survival was 16·6 months (95% CI 15·6–19·1) in the placebo–abiraterone group and 19·2 months (16·5–22·3) in the ipatasertib–abiraterone group (HR 0·84 [95% CI 0·71–0·99]; p=0·043; not significant at α=0·01)."

thelancet.com/journals/lanc...

-Patrick

[treedown]

My genetics report showed PTEN loss and as of today I am hormone sensitive and about to go on vacation in a couple of months to see if treatment with curative intent did what was intended. I will keep an eye on this and do further research. Thank you all.

[Spyder54 in reply to treedown]

Treedown, just the words curative intent get my endorphin flow going. Best of luck on your vacation.

[treedown in reply to Spyder54]

Thanks, hoping it won't be a very short one.

[Spyder54 in reply to treedown]

Right On Man! Right On. Enjoy

[Spyder54]

19% had complete REMISSION caught my attention. Worth testing to learn if your tumours are PTEN deficient! One more piece of the puzzle !!

[Spyder54]

I just heard those words last week when New Oncologist said we’ll see you in 4 months. I said what about Docetaxel. PEACE Trial proved that Lupron + Abi + Docetaxel was better upfront and extended OS by 4+ years (not months). He said not now. Said ADT has PCa cells in senescence. Doxy only works when PCa cells are multiplying fast. Said if I give you 6 doses of Doxy now, it will do nothing. It is better for later. Was he wrong? Did I misunderstand the PEACE Trial? Is it true that Doxy is not effective while on Lupron + Zytiga?