Lupron + Relugolix

[tarzantass]

Hi Guys!

Can Lupron and Relugolix be combined for the treatment of PCa?

Thanks.

[JohnInTheMiddle]

I will guess no. Lupron is an injected GnRH agonist and Relugolix (trade name Orgovyx) is a GnRH antagonist. (Degarelix is the older GnRH injected antagonist, trade name Firmagon.) any of these drugs are collectively known as your basic ADT. It is the foundation of PCa therapy.

So they both are doing basically the same thing but in a slightly different way. (Personally I prefer the antagonist, based on research.) But I have never seen anything about combining the two ever.

But speaking of viable therapy combinations, if you combine one of the ADT drugs above with either an ARPI or an AR antagonist (e.g. Zytiga/Abiraterone or e.g. Enzalutamide respectively) then you have doublet therapy. Specifically hormone doublet therapy.

There are so many permutations and combinations, and complex questions of sequencing, for metastatic PCa drug therapies. And we're not even talking about chemo.

But drug combinations can be powerful. And new powerful clinical trials are revealing more and more all the time about which combinations work. Not all oncologists are up to date on all this.

[tarzantass in reply to JohnInTheMiddle]

Thank you John

[MoonRocket]

The question is why would you combine meds that basically do the same thing...cut T production by the testicles.

[tarzantass in reply to MoonRocket]

Thank you MoonRocket

[Tall_Allen]

No -they do the same thing (lower testosterone) just via different mechanisms.

[tarzantass in reply to Tall_Allen]

Thank you Tall Allen

[MateoBeach]

o need. They are both to stop pituitary stimulation or testicular testosterone prop. So one or the other.