which med for high blood pressure?

[Bspouse]

my husband has been on lupron and abiraterone for almost 3 years now. His blood pressure is consistently high at his monthly lupron shots and his MO suggested that he should start taking blood pressure meds to lower it. Is there a preferred blood pressure med for metastatic prostate cancer? Do any have more or fewer side effects? We are concerned about causing more fatigue or other side effects. What blood pressure meds are others taking? As always Thank you for your advice and best wishes for all on this journey.

[Tall_Allen]

Have you tried increasing the prednisone dose slightly?

[God_Loves_Me]

prednisone may increase blood pressure and sugar too. I do take amlodipine 5mg

[fireandice123]

I take Lisinopril 5 mg. I’ve been on it since well before my PCa dx.

[SweetHomeAlaNana]

mine just started Amlodipine 5mg. Have your husband see his PCP to prescribe and evaluate it. Best of luck

[Gearhead]

Your options, IMO:

1. If you are currently on 5 mg/day prednisone, increase to 10 mg/day (consistent with Tall_Allen's reply)

2. Get a prescription for eplerenone (as an aldosterone receptor blocker, it offsets the BP-increasing effect of abiraterone)

3. Switch from prednisone to dexamethasone (at 1/10 dose)

4. If you aren't already on any conventional BP medications, consult your PCP and MO re starting on one or more instead of any of the above.

FYI, I have been on an ACE inhibitor since before PCa DX. After taking abiraterone for a year or so (I'm now on year 5), my BP increased disturbingly, so I tried a few of the above. I'm now on 0.5 mg/day dexamethasone (no prednisone) plus 25 mg/day eplerenone, which seems to be maintaining my BP at a healthy level.

Good luck.

[vintage42]

I take Cozar (losartan) 100 mg and Hydroduril (hydrochlorothiazide) 12.5 mg. The hydrochlorothiazide replaced Norvasc (amlodipine) 5 mg which I took for a few months but switched because it caused ankle swelling.

[Bspouse in reply to vintage42]

Thank you. I guess we want to avoid amlopidine since he already has some ankle swelling.

[EdBar]

I’m on 3 BP meds, had high BP well before prostate cancer dx. The med that I’ve tried that caused the most fatigue was beta blockers. I had to stop them after a short trial of them. I currently take Amlodipine, Hydralazine and Valsartan.

I suggest your husband get with a cardiologist and see what’s going to work best for him and be sure the cardiologist checks for possible drug interactions with PCa meds he’s currently on. ADT meds are tough on the cardiovascular system so it’s important to be seen by a cardiologist.

Ed

[Bspouse in reply to EdBar]

Thank you. Sounds like we’ll avoid beta blockersHe had EKG and stress test and cardiologist said his heart strong and no issues yet. Curiously he said we should have his GP order blood pressure meds. At the time hubby insisted he doesn’t need BP meds because it’s the ADTthat causes high blood pressure ( which he never had before). Tried drinking beet juice which is supposed to help but didn’t see any improvement. We do know that he has very strong ‘white coat’ reaction because BP is 180+ before his bloodwork and shot and then closer to 160 afterward. We finally convinced him that high BP is not good for you but he wants to avoid any unnecessary side effects so thank you for listing what you are taking.

[EdBar in reply to Bspouse]

Ya I get white coat reaction too, always have. I recommend you get a BP cuff for at home use, much more accurate picture of your BP. If you have an iPhone they have a “Health” app that you can track your at home readings on then show your GP. My GP handles my BP meds too. BTW a 160 reading is kinda high too. My thought is you gotta keep the “machine” in good working condition to fight the fight against PCa. That includes exercise and eating right.

Ed

[Bspouse in reply to EdBar]

Thanks. We have a wrist BP monitor at home but probably should get a real one to be accurate. At home it’s usually near 140.

[Tommyj2]

he really should consult his GP or cardiologist about this….shouldnt just throw BP meds at it and hope. I’ve been taking 100 mg metoprolol and 5 mg amlodipine since well before starting Abi and pred and my BP is rising…..plus I’ve got some ankle swelling now…..time to talk about this with my internist.

[NecessarilySo]

I tried lisinopril but had little reduction in blood pressure, then added amlodipine 5mg and blood pressure greatly reduced.

[Teufelshunde]

ATr blockers improve PC specific survival. I take Losartan.

journals.plos.org/plosone/a...

[Bspouse in reply to Teufelshunde]

This looks promising but his sodium is always below normal so Losartan might not be a good option since it says it can cause low sodium. Maybe there is another ATr blocker ?

[j-o-h-n]

"his MO suggested that he should start taking blood pressure meds to lower it."

Which BP meds did he prescribe?

Good Luck, Good Health and Good Humor.

j-o-h-n

[Bspouse in reply to j-o-h-n]

MO and cardiologist both said his GP should prescribe them. To be honest my stubborn husband has been insisting that, since the ADT causes high blood pressure, he doesn’t needs meds to control it. Finally convinced him that, yes it’s from the ADT, but it’s still bad for your body to have high BP.

[j-o-h-n in reply to Bspouse]

I'm confused...... so what is he doing for his BP issue(s)?

BTW It's not a good idea to use "To be Honest" in posts since it implies that other times you're not honest.

Good Luck, Good Health and Good Humor.

j-o-h-n

[Bspouse in reply to j-o-h-n]

He hasn’t been taking anything for his high BP. It has been getting higher so we know it’s time to try and get it under control.

[j-o-h-n in reply to Bspouse]

The sooner the better.........

Good Luck, Good Health and Good Humor.

j-o-h-n

[RCOG2000]

chlorthalidone has worked well for me

[Professorgary]

curcumin, magnesium and Lisinopril. Amlodipine caused ankle and feet swelling. If you pair every side effect caused by ADT with curcumin and google it you will see it can be of great benefit in many people. From glucose to lipids to bp to fatigue, google them.

[Bspouse in reply to Professorgary]

Good to know. He was taking curcumin for a while but not recently. We will add it back and add magnesium. We’ll suggest lisinopril to GP although it might not lower his BP enough.

[jfoesq]

FYI. I recently got Dx with high BP. My primary prescribed Valsartan.

[mababa]

I started on Orgovyx in February. The worst SEs from the ADT were due to high BP, a result of the Org. They made me doubt I could remain on ADT for more than a year. Was finally prescribed BP medicine (“Lotrel”). What a dramatic change! I feel like I’m back to my old self and it’s hard for me to detect SEs from the ADT anymore. There are other SEs from BP meds, but they’re very manageable so far—don’t even think about them.

[Nikobear]

I used to have blood pressure readings between 150 to 180 all the time, my doctor put me on Nifedpine XL 60mg and Candesartan 32mg, for the last year my readings are between 116 and 130 over 75 as an average, worth checking

[Bspouse in reply to Nikobear]

Thank you! We will mention these to his GP at next visit to see if they would work for him.

[Bspouse]

thank you all for responding. Good to know that lowering his BP could help with other side effects of ADT. Will wait to see what GP suggests, but try to stay away from amlopidine because of the edema side effect.