Diagnosed with stage 4 prostate cancer June 23. Chemotherapy 6 sessions and now on Nubequ. PSA was 147, now 2.4

[PaddyD77]

Diagnosed with stage 4 prostate cancer June 23. Chemotherapy 6 sessions and now on Nubequ. PSA was 147, now 2.4

[j-o-h-n]

And your question(s) is?

Good Luck, Good Health and Good Humor.

j-o-h-n

[PaddyD77 in reply to j-o-h-n]

Has anyone had a similar experience? How long after the treatment before I can expect the cancer in my hip and shoulder start to start becoming an issue?

[MarylandGuy in reply to PaddyD77]

There is no definitive answer. I was on nubeqa and ADT but no chemo and it held it back for 9 months. It could be ten years for you. I am now on a parp inhibitor and it seems to be working.

[PaddyD77]

Only Nubeqa, 2x300mg x 2 per day. Had CT, MRI and nuclear bone scan. Showed up cancer spots in my hip, shoulder and pelvis. 3month check up with bloods only.

[PaddyD77]

PSA is now 2.4. Should it be lower? I thought that's what the Nubeqa is doing??

[PaddyD77]

According to Dr. Google Darolutamide is used to treat a certain type of prostate cancer. This medication belongs to a class of drugs known as anti-androgens (anti-testosterone). It works by blocking the effects of testosterone to slow the growth and spread of prostate cancer.

[PaddyD77]

How did you manage the Doceraxil? I seem to have been lucky as I didn't have any side effects apart from tiredness.

[Maxone73 in reply to PaddyD77]

I have never missed a workout during chemo, even the next day I was working out...EXERCISE is the only thing on which we all agree (and I mean doctors as well) that work wonders, on everything else like diets (apart from eliminate white sugar and eliminate/lower alcohol intake...) you may find some different opinions and research

if you feel tired, do a lighter workout or take more time

[PaddyD77]

Thanks for your kind reply, I have another appointment with my consultant in a couple of weeks. I do feel that I should be having another scan to see if there is any changes since the previous scan. How long between scans is normal?

[Yzinger]

Paddy said he is on Nubeqa - that is ONE kind of ADT therapy right?

Usually combined with Lupron (and the addition of chemo would make it triplet)

[PaddyD77 in reply to Yzinger]

Yes, I believe so. Had the chemo and just on the Nubeqa now.

[Maxone73 in reply to PaddyD77]

you said Prostap injection as well? that's a triplet, normally they start with prostap or something similar, then they add Nubequa and docetaxel within 8 weeks and almost at the same time

[PaddyD77]

I also have an injection of Prostap every six months

[Maxone73]

So you are under triplet therapy as per ARASENS trial. As systemic therapy it's possibly the best you can have at the moment, the only recent one with proven significant life extension.

About your PSA, I suppose you had your first chemo session? (it's one every 3 weeks) I would say that the response is very good for now.

I can give you some stats about survival but remember that everything is individual...

[PaddyD77 in reply to Maxone73]

I'd really appreciate that thank you.

[Maxone73 in reply to PaddyD77]

- Median OS (overall survival) was NR (not reached) vs 48.9 months in the triplet and placebo arms, which means that at least 50.00001% of the patients were still alive at the moment when these info were shared (trials are updated)

- The median time to mCRPC (castration resistance) was NR, whereas in the placebo arm, the median time to mCRPC was 19.1 months, which is associated with worse quality of life and usually also with pain at progression, same goes with radiological Progression Free Survival, not reached

[lcfcpolo]

You have received the new gold standard of treatment, the triplet approach. Unfortunately all of us are different and respond differently but your PSA has responded well, dropping almost 99%. Hopefully it keeps low and maybe even drops more. Best wishes to you.

[PaddyD77 in reply to lcfcpolo]

Thank you for your kind words and encouragement.

[j-o-h-n]

So Mick says to Paddy, See asking questions helps...

Good Luck, Good Health and Good Humor.

j-o-h-n

[PaddyD77 in reply to j-o-h-n]

Got to try to keep smiling 😀😀 even when it's very difficult. I have two young teenage kids and am constantly worried about them and their future, not so much for myself 😔😔

[Mgtd in reply to PaddyD77]

You can say that again.

[PaddyD77 in reply to j-o-h-n]

Got to try to keep smiling 😀😀 even when it's very difficult. I have two young teenage kids and am constantly worried about them and their future, not so much for myself 😔😔