Orgovyx Loading dose -3 tablets

[Tinkudi]

Did all those on orgovyx do the loading dose of 3 tablets or some just start off as one daily.

Any reactions to taking 3 together ?

[Jpburns]

I did the loading dose.

[Tinkudi in reply to Jpburns]

Did you have any reaction. Since how long have you been on it

[Jpburns in reply to Tinkudi]

I’ve been on it since mid-December 2023. Usual side-effects. Brain fog, hot flashes, fatigue…

[USAFproudmom]

My husband did the loading dose. No reaction. He was on it for 6 months, just the same symptoms that others have talked about-hot flashes, brain fog, etc.

[Tinkudi in reply to USAFproudmom]

Thanks. 😊

[johnscats]

Just took one at start doc said that as firmagon injection doesn't wear off for months no need to take 3

[Hawk56]

I did the leading dose. Why not, that's what's prescribed...

I did not notice any immediate reactions nor anything that day.

The next day I began taking the once daily.

Orgovyx had the usual side effects of no T:

Hot flashes

Fatigue

Muscle and joint stiffness

Genitalia shrinkage

Weight gain

They were annoying but not debilitating. I continued to work, exercise, travel.

I came off it in April, muscle and joint stiffness and fatigue dissipated quickly, hot flashes less so, two months later and they are mostly gone.

Kevin

Clinical History

[Tinkudi in reply to Hawk56]

Thank you 😊

[Explorer08]

I did the loading dose in 2021 at the start of my first experience with Orgovyx. I ended up in the ER with bradycardia. Doc told me to stop Orgovyx for three days and restart with just one pill per day. I took Orgovyx for 55 weeks with great results. Then restarted a little over a year later with no loading dose. Again, good results. So many variations in reactions to ADT meds, eh?

[Tinkudi in reply to Explorer08]

Thank you. Did you have any prior rhythm issues before starting it too ?

[Explorer08 in reply to Tinkudi]

Yes, I've had PVCs (premature ventricular contractions) for many years. Also, other meds, like Tamsulosin, have given me bradycardia (I switched from Tamsulosin to Myrbetriq because of that).

[Tinkudi in reply to Explorer08]

Pvcs are considered benign by cardiologists. I get them too and dad does too. My cardiologist also gets them 😀

How much had your heart rate gone down to ? What symptoms did you get - will keep an eye out for those with dad.

[Explorer08 in reply to Tinkudi]

After the loading dose my heart rate went down to the low forties. My heart rate is typically in the mid-50s now. I do exercise a great deal with cardio and weights so perhaps that helps a bit. I agree that PVCs aren't of much concern except, in my case, they've increased by 15% since I've added in Xtandi. I am seeing an electrophysiologist this coming week just for an evaluation.

[Tinkudi in reply to Explorer08]

Good luck 😊. Magnesium tAurate helps me

[wilcoxsaw]

Took loading dose, no side effects.

[FigureGround]

I went from Lupron to Degarelix, briefly back to Lupron, and then to Orgovyx. No loading dose of Orgovyx (never heard of it), probably because I was transitioning from Lupron.

[Dont08759]

I just finished my 10 month Lupron vacation 9 days ago. Took the 3 pill loading dose as indicated from the special pharmacist. So far no side effects, no hot flashes, no lethargy, no digestive changes. I’m still hoping it slows male pattern baldness….

[Cooolone]

Degarelix & it's pill form, Relugolix, don't not cause the FLAIR or Testosterone surge normally experienced with initial Lupron injections. The two drugs are entirely different...

Take the prescription as prescribed!

Good Luck

[mababa]

per their own literature, they want a kick start on the Orgovyx and recommend a 3-tablet starting dose of the 120mg pills. I did this with very little side effect—mostly a slightly disturbed GI. Speaking of SEs, I’ve had no issues with my GI, as some report, but I am having concerning issue with BP.