Has Anyone Used This Combination and What Thoughts Does Anyone Have Regarding the combination. One MO at Moffitt has suggested that I avoid due to moderate interaction causing an increase in relugolix in your body.
Brief info on where I am. PSMA-PET 11/22/22, metastatic spots 2 ribs, 3 vertebrae, numerous lymph nodes from neck to pelvis. 12/27/22 Total PSA 7.3, free PSA 3.9. Prostate removed 08/2015, 39 radiation treatments Summer 2019 and 5 high dose treatments to 3 lymph nodes and 1 spot on lilac bone along with Eligard fall of 2021. Last Eligard 12/21.
Thanks in advance for your thoughts.
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Wynnsts
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TA, no they did not give any info other than the combination would make me a higher risk for side effects. Am I wrong in thinking that Eligard/Lupron combined with Xtandi or even Zytiga or Erleada(?) would create a similar higher risk due to side effects. The MO proposing Orgonyx and Xtandi gave me a study published in The New England Schools of Medicine dated 06/04/2020 and I didn’t find anything indicative and interaction, sometimes I miss thinks reading. I’m going to give it a go, I think I like the idea of oral form. Again, thanks for your input.
Wouldn't Zytiga be the better choice for a first second level ADT than Xtandi. Is it possible Xtandi is being prescribed now by doctors perhaps due to profit motive now that Zytiga has gone generic.
Quite easy and done all the time. Drug reps get Doctors to prescribe a new or expensive drug for incentives.Pharma payments to physicians still deliver a big 'return on investment' in prescription growth, study finds | Fierce Pharma
Thank you sir, maybe our paths will cross at Moffitt one day. Great place, I’ve been with them since late 2018. I’m also seeing a MO at TGH Cancer Institute, another great facility. Best of wishes in your journey!
What is the reasoning behind that? I have been taking both around dinnertime. I have only been on this combo for 6 weeks but both say can be taken anytime. Is there an advantage?
“Avoid coadministration of ORGOVYX with oral P-gp inhibitors. If coadministration is unavoidable, take ORGOVYX first and separate dosing by at least 6 hours. “
Enzalutamide is a P-gp inhibitor. Mild, but it’s metabolite even more so. Therefore, the administration should be separated by at least 6 hours.
Yes, separately they each can be taken at any time, with or without food in our house, breakfast is around the same time every day. Dinner time is more widely variable, plus we are more likely to find ourselves in restaurants in the evenings. Since Orgovyx really needs to be taken consistently at the same time of day, first thing in the morning seemed the safest bet for not missing a dose. He has not missed a dose in the 14 months he has been on it
First off .. I do not trust the MO's at Moffitt for many reasons. First ad foremost they will not talk to any other Dr.s.. I have two teams at the Mayo Clinic in Rochester MN and Jacksonville Fl. The Dr.s in both of those hospitals are more than willing to share their findings with my "team" I use the term loosely at Moffitt but sadly the Moffitt MO's think who they are... It's a joke.. BTW my team at the Mayo is headed up by Dr, Kwon who is way more qualified and compassionate than my MO at Moffitt... PLEASE don't get me started. Moffitt did not want to give me a PSMA Pet scan because they do not have any new doses of LU-177 until march or April.. but if the mean time.. Mayo said.. if you get a PSMA scan at Moffitt have te results sent here and w will review it and should you be eligible we can start treatment with LU-177 immediately. .. "Why would you want to wait" three or four months to possibly let your disease advance? That's just one of the differences between Moffitt and Mayo.
Larry, I do understand a bit of what you’re saying, but mine pertains to the Gastro group at Moffitt. I’ve only had one visit with an MO at Moffitt in the 4+ years I’ve been treated there. In a colonoscopy they discovered cancerous polyps and 16” of my colon was removed. This group would not talk to you(me) or anyone else. The Radiation Department has been great, but MO wise I have no opinion as of yet. I’m talking with Dr Mayer Fishman at TGH Cancer Institute presently and he suggested this combo for the next year at least. Happy New Year and Best wishes in your journey.
Thanks Larry CT that’s great to hear. My wife and I were so excited after meeting with Mayer. He was fantastic and we’re excited about continuing our journey with him. 2023 will be a great year for both of us!!
It was my understanding that they wanted to see if the radiation elimated the cancer or whether the Eligard suppressing its’ growth. And being honest it didn’t take a lot of talk to get me to quit Eligard.
I know several guys who use it intermittently with great results. The fact.that they are oral allows it. Orgovyx is super hard on the whole body so just know it.
I haven’t heard this about being hard in the whole body, but I’m very interested. Could you direct me to some info on this. Thanks so much for this info. I hope you have 10 more years fighting this stuff!! Happy New Year, May it lead to a cure!
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puzzled with Orgovyx 
Stopping Xtandi due to Neuropathy 
Enzalutamide (Xtandi) or not
Xtandi
