About renal carcinoma, but expanding ... - Advanced Prostate...

Advanced Prostate Cancer

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About renal carcinoma, but expanding to solid tumors: allogenic CAR T therapy...CRISPR based!

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allogenic means that it's off the shelf, no need to use your own cells and grow them, reducing time and cost involved...

"This study is proof of concept that we can do something [with CD70-directed CAR T-cell therapy] in the solid tumor space, and hopefully we can [go on to] induce durable remissions and cure [patients] based on these results."

"The resulting CTX131 construct they designed includes two modifications, and preclinical data suggest that CTX131 will have superior potency and efficacy vs CTX130. Based on these data, investigators have launched a phase I/II study to assess the safety and efficacy of CTX131 in adults with relapsed or refractory solid tumors (ClinicalTrials.gov identifier NCT05795595). "

ascopost.com/news/may-2024/...

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