Experience/Opinions on: Pembrolizumab... - Advanced Prostate...

Advanced Prostate Cancer

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Experience/Opinions on: Pembrolizumab + Lenvatinib for NEPC/SCPC

skiingfiend profile image
13 Replies

In January I was diagnosed with SCPC with liver metastasis.

My first line of treatment was Platinum based chemo (carboplatin+etoposide). This treatment failed after 3 infusions with radiographic progression on CT Scan.

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...

HEPATOBILIARY: Innumerable bilobar hepatic metastasis have progressed. There are several new lesions and enlargement of the pre-existing lesions. For instance, a 1.5 x 1.1 cm lesion in segment 7 is now 2.7 x 2.5 cm. There is mass effect narrowing the hepatic vessels but the portal and hepatic veins remain patent. No biliary dilation the gallbladder is unremarkable.

...

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For the 2nd time this year, I was given an estimated 90 days to live without effective 2nd line treatment. Also my MO seems to stand behind this estimate since he has registered me with BC Palliative Care Program (6 mo's to live).

At my urging, my MO reached out to US based Clinics in Seattle, Portland and San Francisco with the goal of seeking out clinical trials relevant to my condition.

Within 1 week I have a spot reserved on the PLANE/PC trial contingent on meeting the eligibility requirements. We are in the processing of working thru that now and I will probably have to travel to Oregon in the near future.

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Does anybody have any experience with or opinions on this trial:

PLANE/PC - Phase 2 - Pembrolizumab + Lenvatinib

clinicaltrials.gov/study/NC...

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skiingfiend
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13 Replies
Tall_Allen profile image
Tall_Allen

I am intrigued by this trial, which is scheduled to begin next month:

clinicaltrials.gov/study/NC...

skiingfiend profile image
skiingfiend in reply toTall_Allen

Just generally intrigued, or something more specific?

Tall_Allen profile image
Tall_Allen in reply toskiingfiend

I like that it is tailored to each patient's type of small cell PCa.

Believeit profile image
Believeit in reply toTall_Allen

That’s a very interesting trial. We will check it out also. Thank you.

gsun profile image
gsun in reply toTall_Allen

The link didn't work for me

skiingfiend profile image
skiingfiend in reply togsun

Hmm. I just checked it, worked for me.

You can look it up by trial no:

Clinical Trial No: NCT04848337

God_Loves_Me profile image
God_Loves_Me in reply toTall_Allen

Great !!!

Yadifan profile image
Yadifan

Don't have any experience to offer but wishing you good luck with this trial. Hoping you get the answers you need and that you qualify. Keep us posted.

j-o-h-n profile image
j-o-h-n

Of course you know, that I wish you master this new slope....

Good Luck, Good Health and Good Humor.

j-o-h-n

skiingfiend profile image
skiingfiend in reply toj-o-h-n

Thanks, I gotta keep on trucking while I'm still kicking.

TeleGuy profile image
TeleGuy

This study: NCT02861573 has been around for a while and includes at least one arm that combines the same two drugs. It was on my treatment buffet for a bit before deciding to try PT-112 (which didn't work for me, at least for long). It's part of the KEYNOTE series of trials that seem to be funded to look for combinations of drugs with pembrolizumab that are effective. I'd poke around and see if you can find any results.

skiingfiend profile image
skiingfiend in reply toTeleGuy

I've talked to some MO's about the trial. It's not overly encouraging. I'll post a synopsis of the conversations a little later after I collect some more information from the Clinical Resource Coordinator.

I've already decided to start Docetaxel immediately and push CT's as a possible line of treatment into the background.

TeleGuy profile image
TeleGuy in reply toskiingfiend

My first tx once we discovered my NE component was docetaxel + carboplatin, hopefully the docetaxel will get what the carbo didn't!

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