cancer progression

[Juju0713]

Hello, please see my profile for history on my dad's condition. He went to the ER this weekend with severe flank pain and CT revealed left-sided hydronephrosis as likely cystic soft tissue mass obstructing the left ureter. An anterograde stent was placed after failure of retrograde stent. The cancer has progressed since his last CT in February. Will his next option here most likely be another round of chemo since the cancer is showing radiographic progression? Or what would potential other options be? He will be meeting with his MO this week. Thank you

[Shams_Vjean]

If you’re in the USA he might qualify for Pluvicto, but will need a PSMA PET scan to determine if concordance is high enough. Although if he has kidney disease Pluvicto may not be a good fit for him.

I think there may also be some stage 3 trials open which combine BRCA targeted treatments with other SOC therapies. Tall_Allen would likely know about these, if any exist currently.