Does NSAIDS reduce ADT effectiveness?

[jackwfrench]

Hello I have a question about taking NSAIDS while on ADT - up to now I have only used tylenol - I had read somewhere that NSAIDS subtract some effectiveness of the hormone therapy and I have avoided it - but with the amount of inflammation after 8 months, I would like to use some - primarily to let me sleep, does anyone have a comment about this?

[Tall_Allen]

No they do not.

[pd63]

If on other meds including blood thinners/ anticoagulants NSAIDS could be contradicted leading to higher chance of bleeding please be aware

[Kaliber]

I was prescribed prescription strength NSAIDS and within 30-40 days, my liver enzymes elevated to dangerous levels. It would be good to discuss this in depth with your medical team and watch things like , ..alt, atp, ast and urine microalbumin. You can do urine microalbumin tests at home with OTC urine tests. Just my IMHO, your circumstances will surely be personally dependent … your medical team will sort it out for you. Just what happened to me.

❤️❤️❤️

[EdBar]

I was prescribed Celebrex by Dr. Sartor for ADT related side effects so the answer would be no.

Ed

[SteveTheJ]

Anecodotally, no. I use anti-inflammatories as needed for a variety of things, recently for back pain. It's common sense to me: Tylenol, Advil, and all of them (except maybe Celebrex) can affect the stomach. Tylenol and Advil can damage the kidneys and liver (I forget which is which). Don't overdo them.

No reason to avoid them but set your limit and stick with it. If you don't feel the need, don't take them.

My PSA has been unmeasurable for >4 years so from my perspective, I continue to take them as needed.

[tunybgur]

I take low dose aspirin as I understand it increases resolvins which help clear up dead cancer cell debris which can be a seed bed for new cancer cells to develop.

There are papers on this, only aspirin does this though....

isbscience.org/news/2017/11...

[jackwfrench in reply to tunybgur]

However hormone therapy would not seemingly destroy cancer cells that aspirin could clean up, it just puts the cells to sleep

[tunybgur in reply to jackwfrench]

Not quite sure if I follow you,,,,,

[Catmama5 in reply to tunybgur]

I think the point is that if the cancer cells are put to sleep, rather than killed, that there would not be cell debris that acts like stem cells for cancer to grow. This is theory, not fact in my opinion.

[tunybgur in reply to Catmama5]

Hormone therapy blocks testosterone which the cancer cells need to grow and multiply, so aspirin should hopefully help to clear up dead cancer cell debris from existing cells which have been killed by RT and/or chemo.

Not sure I see any downside if that's how it works.....

[jackwfrench in reply to tunybgur]

Yes I think thats right - I didnt have RT or chemo, just HT so no benefit for aspirin for me yet.

[j-o-h-n]

For simpletons like me who hate abbreviations/acronyms:

Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of medications used to reduce pain, inflammation, and fever. They are also known as en-saids. NSAIDs are often used to relieve symptoms of: Headaches, Painful periods, Sprains and strains, Colds and flu, and COVID-19 conditions such as arthritis.

Good Luck, Good Health and Good Humor.

j-o-h-n

[Professorgary]

I take 200 mg of Celebrex X2 times daily with 2800 mg of curcumin. Google curcumin and Celebrex to fight prostate cancer and you’ll find some interesting reading. Also get a doctor and get Celebrex and stay away from non selective cox inhibitors as drugs like ibuprofen block the cox 1 enzyme which protects the gastric tract.

[jackwfrench in reply to Professorgary]

What do you think about naproxen? I used it for years prior to cancer.

[jackwfrench]

Fascinating! I do find a few things on it, but can you share, privately if you prefer, your overall strategy on this and any apparent results? I do take only 500mg circumin daily now. Exciting to think I can find a better approach than NSAIDS -better for recurrent prostate cancer, and inflamation (of which I have much!).

[Professorgary]

I only used Naproxen a few times over the years for back pain. I had no real problems with it but it was short term treatment. When my Orthopedic doctor told me I’d be on NSAIDs forever I researched them because the ibuprofen I was taking caused me to have minor gastric issues. When I googled Celebrex and curcumin together a webpage popped up that showed some evidence that together they may slow castrate resistance in adt patients. Without the curcumin you have to take toxic doses to get the same effect. Also adt and Celebrex can be hard on kidneys and liver but curcumin cleanses the liver and kidneys. My liver enzymes are normal but before curcumin my bilirubin ran high and my kidney flow rate was 89. Since taking curcumin my kidney flow has been steady at 117.5 and bilirubin is normal. Hope this helps, God bless.

[jackwfrench in reply to Professorgary]

Thanks now I understand your case better - after more reading it seems for me naproxen is a better choice than ibuprofen in the presence of prostate cancer.

[Professorgary]

Sorry, the above comment is for jackwfrench. I must have hit the wrong key.