Update April 5, 2024

[MsHope]

UPDATE: April 27, 2024

My husband's PSA decreased 1144 points this last month. We are so excited to see this decrease. His PSA Is still high 586, but we are on the right track now. His other blood work has been good as well. He got his 6 month Lupron shot last month and that might have caused the decrease, we don't know. Doctor said take a break on chemo for right now. Going to get a PSMA PET-CT in a couple of weeks. Doctor will then decide what treatment plan will be after that.

Does anyone have ideas why PSA would drop so drastically?

Wishing all others good health too.

UPDATE: April 5, 2024

Yesterday was very disappointing as my husbands PSA increased again by 183 points, last month his PSA was 1546 and now it is 1730. All his other CBC results were good. His Alkaline Phosphatase increased 6 points, last month 127 and now 133 but still in range of 40-150. Questioned why PSA was increasing each month. Only explanation was maybe his 6 month Lupron injection had worn off. Yesterday was his time to get Lupron injection. I have a hard time believing that is the cause. He feels good, has gained weight and no significant pain since starting chemo. I asked about the post chemotherapy syndrome and was told that was not the cause, as it only last the first couple of chemo treatments.

Wants him to have another PMSAT scan. Ask it that would tell us why PSA is increasing and was told it would show any active cancer cells. That didn't answer our question. We will decide on that after next chemo treatment.

Any insight to this issue would greatly be appreciated.

[Still_in_shock]

Might not be the cause.

So you know a 6 month Lupron shot is 24 weeks not 26.

[MsHope in reply to Still_in_shock]

Thanks for response. He has been getting Lupron right on Schedule since 2018

[Tall_Allen]

His T level would tell you if his Lupron wore off. He may want to have both an FDG and a PSMA PET scan. His next therapy would be Pluvicto, and he would need both to determine whether Pluvicto might be beneficial.

[MsHope in reply to Tall_Allen]

Thanks so much for your reply. His T level <3 ng/dL. Doctor just said that if his Lupron was getting to the end cycle before his next injection was due, it might cause PSA to rise. Monthly CBC does not include T Level test every month, last one wa in2021. Told us might have to change treatment to Cabazitaxel (Jevtana). How would a FDG or PSMA help in showing why PSA is increasing when having chemo treatment?

[Tall_Allen in reply to MsHope]

The goal is to slow his progression, not to explain a rise in PSA. It doesn't matter why his PSA has failed to respond. It only matters that the cancer has not responded, and what it's worth trying next.

[Jost-58]

which you all luck with upcoming treatments.

[God_Loves_Me]

Have you talk doctor about enzalutamide, or apalutamide and darolutamide ?

[MsHope in reply to God_Loves_Me]

Thanks for reply. Was on Xtandi and it worked for a short time then on Zytiga which did not work at all

[MsHope]

Woodstock82, I saw a reply to post you previously made for another person. Your story is just like my husbands. I would appreciate any input you might have on my post.

[Woodstock82 in reply to MsHope]

MsHope - Tall Allen put it succinctly, I don't have anything significant to add. When I was started on cabazitaxel, Pluvicto was not yet available. When I progress and need another therapy, Pluvicto will be my first choice.

[Teacherdude72]

I have spoken to many medicals about Lupron and extended months shot.The first time I was in Lupron it was monthly shots for the first 8 months, then two four month shots. I personally felt the side effects lessoned a few weeks before the next shot. Mentioned that to the PA & MO. Both admitted that the shots didn't last as long as states for many patients.

I was on that round of Lupron two years.

Several years later I was again on Lupron/Eligard and was, once, given a 6 month shot. Was not my choice. My PSA doubled twice in 4 months. Was back in monthly Lupron at that point. Added Numbers. Did those together for 33 months and PSA dropped to <0.02.

[MsHope in reply to Teacherdude72]

Thank you so much for your reply. I hope that is my husbands case, and Lupron will kick in again and lower his PSA for his next appt on April 24th.

[Teacherdude72 in reply to MsHope]

You are Welcome.Best Wishes and Prayers

I am on my ninth year and on Holiday from my Cancer meds per MO suggestion. At 76 life is good.

[MsHope in reply to Teacherdude72]

You gave me good info last time. Wanted to let you know, He got his 6 month Lupron shot last month 3/24. PSA decreased 1144 points from last month. We are so excited to see this decrease. His PSA Is still high 586, but seems we are on the right track now. His other blood work has been good as well. He had his 6th chemo treatment on 4/25. Doctor said take a break on chemo for right now. Going to get a PSMA PET-CT in a couple of weeks. Doctor will then decide what treatment plan will be after that.

[Teacherdude72 in reply to MsHope]

Glad to help. Positive attitude is a big plus. As I said I am on Holiday from meds and all good so far. The one medication that helped me attain <0.02 psa was Darolutamide, Nubeqa common name.

Again Best Wishes for great results.