2nd Dose at Sarah Cannon Research

[Pmann]

Morning folks,

Finishing second dose of XmAb808

and all is well so far.

Blood work looks good and have to wait four hours post dose.

On Cipro for UTI and that is better too

Let’s kill those cancer cells

[KocoPr]

excellent!

cancer.gov/publications/dic...

anti-B7-H3/CD28 bispecific antibody XmAb808

A bispecific antibody directed against the tumor-associated antigen (TAA) and immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and the co-stimulatory T-cell surface glycoprotein CD28, with potential immunostimulating and antineoplastic activities. Upon administration of anti-B7-H3/CD28 bispecific antibody XmAb808, this bispecific antibody binds to both B7-H3 on certain tumor cells and CD28 on cytotoxic T-lymphocytes (CTLs). This activates and redirects CTLs to B7-H3-expressing tumor cells, which may result in the CTL-mediated cell death of B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of the T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis.

[Pmann in reply to KocoPr]

Thank you for the kind words.

That is the trial.

I am still on Eliguard.

I did have gene testing and it did show one wacko gene.

Cannot locate it right now under massive pile of medical records.

I did not show link to prostate directly but to ovarian cancer and a child blood disorder.

[KocoPr in reply to Pmann]

On your wacko gene if it was awhile ago i would search to see if any new info came out on it. They are constantly adding more genes to the PCa list.

I always research my gene mutations looking for new research and possible treatments.

[Pmann in reply to KocoPr]

The genomic testing was last October, and it was discussed with Dr. at SCRI as an option but this trial seemed better and a slot came open so this is my path. Thanks for the input.

[KocoPr in reply to Pmann]

It’s a good path!

[KocoPr]

is this the trial?

cancer.gov/research/partici...

Phase 1, First-in-human, Dose-finding and Expansion Study to Evaluate XmAb®808 in Combination With Pembrolizumab in Advanced Solid Tumors

Exclusion Criteria

Subjects currently receiving other anticancer therapies

Do they mean you are not on any ADT?

[KocoPr]

wow! Reading your bio you road that treatment train for 24 years! Your a true survivor and warrior.

Out of curiosity did you ever get genetic testing? Germline, somatic, liquid biopsy?

[85236442968]

Pmann

What a journey you have been on.

You must be the Alpha Warrior on this site.

Best of luck on the trial and your future.

I am the same age as you.

[j-o-h-n]

At 25 years you get a gold watch.......keep up the good work.....

Good Luck, Good Health and Good Humor.

j-o-h-n

[j-o-h-n]

Sorry, make that plated.........

Good Luck, Good Health and Good Humor.

j-o-h-n