Anyone know anything about this drug. Company stock shot way up this week on announcemnt of positive results from initial trials. Where are the trials? Wonder if it would be worth persuing. Here is the headline:
Janux Therapeutics rocketed up 230% Tuesday, tripling in value, after unveiling promising results in trials for its prostate cancer treatment
It's one of the many BiTE therapies in trials now.
Thanks TA....to bad we didn't own some stock. Here is a portion of the report
I am trying to put off chemo, but have to do something. This trial may help?
"In one dosing group, 83% of patients saw their PSA levels decline by 50% following treatment with Janux's drug. PSA, or prostate-specific antigen, is a key marker in determining the presence of prostate cancer. In another dosing group, 56% of patients hit the same mark."
I think they all require chemo first.
This is what the Inclusion Criteria for JANX007 says:
"Participants who have actively refused a taxane containing regimen or are medically unsuitable to receive taxane are eligible"
It's tragic when patients who are suitable, refuse chemo.
I'm 90% sure chemo will be my next move within the next month unless i can get into a good trial. In this case if i said i was actively against chemo i might qualify or am i reading that wrong?
Also, regarding taxatere, my MO said he would prescribe once a week dose for 18 weeks. I thought the norm was a dose every 3 weeks for 18 weeks?
Every 3 weeks at 75 mg/m2 tested significantly superior to 30 mg/m2 weekly doses:
"Bi-specific T-cell engagers (BiTEs) are a class of artificial bispecific monoclonal antibodies that are investigated for use as anti-cancer drugs. They direct a host's immune system, more specifically the T cells' cytotoxic activity, against cancer cells. BiTE is a registered trademark of Micromet AG (fully owned subsidiary of Amgen Inc).[1]"
en.wikipedia.org/wiki/Bi-sp...
Very interesting
I hope it turns out better than provenge.
Have you had Provenge? A recent post (or responses to it) indicated it extended life. What's the downside?
I haven't had it.I would take if recommended by a Doc
But it just doesn't work as well as was originally hoped for.
Apparently it got off to a bad start. Very pricey, company went into bankruptcy, and competing therapies with similar efficacy were approved and released shortly after it appeared. Sounds like something to just consider in the mix from what I've seen. I notice PCF's annual guide mentions it somewhat glancingly.
My hospital and my onco (who is medical director of the cancer center) said they stopped using Provenge because of its limited benefit. He had one patient who was turned "loopy" by Provenge
Thanks. I knew there had to be an elephant in the room, as discussions of it on forums I read are minimal. But I guess a small benefit was shown in trials.
So glad to read there is another avenue to venture into soon, I hope. Now after a number of chemo infusions over the past 2 years, I am on a double treatment plan of Nubeqa and Lynparza. My PSA when I started the last rounds of Docetaxel/Carboplatin 01/2023 was at 760 and dropped to 176 after 6 months, even with reduced amounts of chemo, due to very low blood counts. I would love to go back to the chemo because of such good results, but my bone marrow would probably not handle it. PSA now at 311 but looking to see it drop with next lab.
Keep strong everyone, prayers to all that suffer.
you are on nubeqa and lynparza at once? My doctor had me switch off of nubeqa and on to lynparza as by psa started to rise after six months of being low on nubeqa.
No I was on lupron and nubequa. I had been on lupron for 12 yrs when they added nubequa because of rising psa. Lynpraza seems to be if you have the Braca gene?
Yes on both at present. Finishing the 3rd week on Lynparza and will probably reevaluate after lab on Friday and onc visit in a week.
My options are running out so willing to try what is still out there .
Thanks for your reply…
My lab Friday was not what I wanted to see, psa up to 440 so I will question keeping on Nubeqa. In fact maybe I should drop both and start a new treatment. I’ve mentioned to my oncologist that Xtandi has been revisited by many with good results. Maybe that is my next best option.
Any suggestions are appreciated since I’m about out of options.
Out of my area of expertise. Perhaps TA has some advice?
Respectfully Sir,
I often contemplate what I would have done differently in my treatment or what I would do now if I were older. I was diagnosed at about the age of 56 already spread to pelvic lymph nodes, and now has metastasized a bit further. I did RP, Lupron, Chemo, and Radiation. My PSA was undetectable, scans were clean. I took a Lupron holiday and now at 18 months, PSA creeping up and scan shows seven spots up my body. I am 61 years old now, and want to know where I am going, and what I am doing? I tell myself if I were this age or that age I wouldn't do anything. What words of wisdom can some of you wiser gentlemen offer?
At 57 I had Taxatore, Lupron, and Radiation. 4 1/2 years later I still have Radiation side effects, and look back thinking the Chemo was the easy part.. Chemo was what I feared the most but in my opinion Radiation was worse.
Question on stopping ADT - Keytruda/pembro 
177LU-DTPA-SC16 attaching DLL3 for neuroendocrine cancer
Metformin: Preliminary Results of Trial in Advanced Prostate Cancer (MANSMED)
